TTP: EEG Delta Activity Correlates With Transient Aphasia, Resolves With Treatment

Thrombotic thrombocytopenic purpura (TTP) is a rare microangiopathic disorder that, if untreated, carries a mortality rate exceeding 90% [1, 2, 3]. Its core features include microangiopathic hemolytic anemia and severe thrombocytopenia, frequently complicated by neurological and renal dysfunction [4, 2]. Neurological symptoms are a hallmark, often presenting as a fluctuating constellation of headache, altered mental status, and focal deficits that can pose a significant diagnostic challenge [5]. The precise electrographic and neuroimaging correlates for these dynamic presentations are not consistently defined, creating uncertainty in clinical management and highlighting the need for objective markers to guide rapid, life-saving therapy [6, 5].