Smoking Cessation Reduces Dementia Risk, But Weight Gain May Attenuate Benefit
A large prospective cohort study indicates quitting smoking lowers long-term dementia risk, though substantial post-cessation weight gain may…
Read Article →
ERV Reactivation Drives C4b-Mediated Synaptic Pruning in Autism Models
In mouse models, endogenous retrovirus reactivation leads to C4b upregulation and excessive microglial pruning, contributing to autistic-like…
TTP: EEG Delta Activity Correlates With Transient Aphasia, Resolves With Treatment
A case report details how left temporal lateralized rhythmic delta activity (LRDA) on EEG tracked fluctuating aphasia in TTP, resolving with targeted
Tau Aggregates Drive Neuronal Death via ZBP1 Activation in Tauopathies
A new study identifies a molecular cascade where tau aggregates reactivate transposable elements, leading to Z-RNA-ZBP1-mediated neuronal death.
Low-Dose Buprenorphine Sustains Ketamine's Antisuicidal Effects in MDD
A randomized trial indicates sublingual buprenorphine extends ketamine's rapid reduction of suicidal ideation in major depressive disorder.
Updated Appropriate Use Criteria for Amyloid and Tau PET: A Report from the Alzheimer’s Association and Society for Nuclear Medicine and Molecular Imaging Workgroup
Amyloid and Tau PET Appropriate Use Criteria
Trial Watch
-
IL-6 Inhibition Shows Clinical Signals in Refractory Depression
-
Remote Multicomponent Rehabilitation Does Not Improve Quality of Life for ICU Survivors
-
AD109 Reduces Apnea-Hypopnea Index in PAP-Intolerant OSA Patients
-
Multimodal AI System Matches Clinicians in Simulated Telehealth Diagnostics
-
Digital Therapeutic App Reduces Chronic Tinnitus Distress in Randomized Trial
-
Interdisciplinary Whole Health Teams Improve Chronic Pain Function Over Standard Care
New Guidelines
-
LANCETP launches 2025 guideline for Algorithmic Treatment of Schizophrenia
-
AA and SNMMI launch 2025 guideline for Amyloid and Tau PET Appropriate Use Criteria
-
CANMAT and ICOCS launch 2025 international guideline for Obsessive-Compulsive Disorder
-
CANMAT launches 2024 guideline for Major Depressive Disorder Management
-
CANMAT launches 2024 guideline for Perinatal Mood, Anxiety, and Related Disorders
-
Alzheimer's Association launches 2024 guideline for Alzheimer's disease and related dementias
Latest
-
Noradrenaline-Amygdala Circuit Modifies Aversive Memories During Recall
-
Neurobehavioral Profile of Young Steroid-Naive Boys With Duchenne Muscular Dystrophy
-
Autoimmune Encephalitis Subtypes Identified in Rapidly Progressive Dementia
-
Plantar Agraphesthesia Signals Lower Limb Cortical Sensory Loss in Corticobasal Syndrome
-
Maternal Microbial Exposure Confers Intergenerational Stress Resilience in Male Mouse Offspring
-
VTA-mPFC Dopamine Circuit Drives Stress-Induced Sleep Fragmentation in Mice