Planetary Health Diet Linked to Lower Risk of Stroke and Depression
A UK Biobank study of 69,370 adults finds high adherence to sustainable eating reduces brain disorder risk via slower biological aging.
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Resilience Alters Symptom Networks Linking Bullying to Depression in Adolescents
Network analysis reveals that low resilience strengthens the ties between social exclusion and depressive symptoms like anhedonia.
Rising Depressive Symptoms Precede Cardiovascular Disease by Over a Decade
A longitudinal analysis of nearly 50,000 adults identifies a sustained increase in depressive symptoms as a long-term prodromal phase of CVD.
Early DHEA Levels Predict Depression in Adolescent Males but Not Females
A longitudinal study finds that while DHEA at age nine increases risk for males, adrenal hormones do not explain higher female prevalence.
Home-Based Prefrontal Cortex Stimulation Reduces Subjective Stress Appraisal
A feasibility study of self-administered tDCS shows high adherence and safety, though physiological stress markers remained unchanged.
Four Months of Fingolimod Does Not Improve Anxiety or Depression in MS
A prospective study of 61 patients with relapsing-remitting MS found no significant changes in mood scores after initiating fingolimod.
Students With Moderate Distress Show High Rate of Worsening
A 10-month analysis finds this group is a key target for intervention, with problematic internet use predicting negative outcomes.
Australian Military Abandons Stratified Suicide Risk for Collaborative Safety Planning
A system-wide initiative removed low, medium, and high risk labels, training over 72,000 personnel in member-centered risk formulation.
Activities Counter Negative Affect in Depressed, Anhedonic Youth
Real-world data show leisure and social company improve mood primarily by decreasing negative affect, not by increasing positive affect.
Adolescent Nicotine Rewires Brain Circuitry to Boost Opioid Reward in Mice
Early nicotine exposure alters GABA signaling in the ventral tegmental area, amplifying the rewarding effects of morphine in adult mice.
Menstrual Cycle Phases Alter Brain Reactivity to Drug Cues
Functional MRI reveals that estrogen heightens cue-induced craving in women with substance use disorders, while progesterone blunts it.
Alexithymia and Poor Coping Link Trauma to Self-Injury in Depressed Youth
An inability to process emotions drives maladaptive coping, forming a chain reaction that connects early trauma to adolescent self-harm.
Early Famine Exposure Linked to Accelerated Functional Decline in Older Adults
Nutritional deprivation during fetal and preschool development increases the risk of rapid intrinsic capacity deterioration by over 50 percent.
Mental Health Gains Tied to Cessation, Not E-Cigarette Switching
A large study links complete cessation to better mental health over time, a benefit not seen in those who switch to e-cigarettes.
Maternal Depressive Symptoms Nearly Double Preeclampsia Risk
A meta-analysis of over 44,000 pregnancies shows early depressive symptoms significantly elevate the risk of hypertensive complications.
Hippocampus-Thalamus Circuit Drives Contextual Hyperactivity in PTSD Mouse Model
A specific glutamatergic pathway may be a therapeutic target for context-dependent arousal symptoms.
Nicotine Rewires Habenular Circuits in Mice, Altering Food Motivation
Chronic nicotine exposure in mice disrupts top-down control of the LDT-VTA cholinergic axis, driving exaggerated food-seeking behavior.
Vitamin C Reverses Depression-Like Behavior in Female Mice via D2 Receptors
A single dose of ascorbic acid restored dopamine D2 receptor signaling in the prefrontal cortex, rapidly alleviating depression in mice.
Inhibiting RhoA in Rat Prefrontal Cortex Reduces Morphine Dependence
Blocking the RhoA pathway in rats reduces opioid-induced neuroplasticity and limits glutamate spillover, offering a specific addiction target.
Epigenetic Target HDAC5 Reduces Environment-Triggered Cocaine Seeking in Rats
In a rat model, overexpressing the enzyme HDAC5 in the prelimbic cortex shifted synaptic balance to suppress context-driven cocaine seeking.
Cognitive Status Remains Key Predictor of Dementia Risk Alongside p-tau181
ARIC data show that while p-tau181 is prognostic, the absolute risk of dementia remains low in cognitively unimpaired individuals.
Young Children Require Higher Benzodiazepine Doses for PICU Ventilation
A retrospective cohort study reveals that children under five receive significantly higher weight-adjusted doses of midazolam and lorazepam.
Social Anxiety Affects Nearly Half of College Students
An analysis of 5,996 students reveals a 47.9% incidence of social anxiety, with gender, grade, and physical activity as top predictors.
Caffeinated Coffee and Tea Lower Dementia Risk; Decaf Shows No Benefit
A 43-year prospective study of 131,821 adults reveals that 2 to 3 cups of caffeinated coffee daily significantly reduces incident dementia.
Cross-Ancestry Analysis Identifies Shared Genetic Risk for Major Psychiatric Disorders
Researchers identified 403 genetic loci and specific cellular pathways common to schizophrenia, bipolar disorder, and depression.
Apps for Alcohol Use Do Not Improve Mood Beyond Standard Care
In a randomized trial, digital tools added to standard care did not further reduce depression or anxiety in adults with alcohol dependence.
Intracortical Implant Enables Paralyzed Patients to Type 22 Words Per Minute
By decoding attempted finger movements, a neuroprosthesis allows patients with tetraplegia to type on a virtual QWERTY keyboard.
Opioid Medications Halve Mortality but Reach Only a Quarter of Patients
A clinical review details how optimizing methadone, buprenorphine, and naloxone can close the treatment gap and reduce all-cause mortality.
Structured Exercise Improves Sleep and Executive Function in Preteens With Autism
A 10-to-12-week physical activity program objectively reduced sleep fragmentation and improved problem-solving in children with autism.
White Matter Damage Drives Cognitive Decline via Two Distinct Pathways
In amyloid-negative patients, periventricular lesions directly impair memory but indirectly drive executive dysfunction via hypometabolism.
Schizophrenia Patients Lack Neural Mismatch Response to Unmasked Faces
Patients with schizophrenia fail to generate a normal brain response when internal predictions of a face conflict with new visual input.
Plasma p-Tau217 Matches PET for Modeling Alzheimer's Timelines
Plasma p-tau217 accurately estimates the onset of amyloid and tau pathology, offering an accessible alternative to expensive PET scans.
Altered Cortical Myelination in OCD Links to Specific Symptoms
A multisite MRI analysis reveals that adults with obsessive-compulsive disorder show altered intracortical myelination in frontal regions.
Web-Based School Program Reduces New-Onset Mental Health Problems
An eight-session internet intervention focused on stress management lowered the one-year incidence of mental health issues from 28% to 21%.
Paid Social Media Boosts Community Outreach in Prehospital Trials
A retrospective review of a 20-site pediatric trial shows paid Facebook ads reach significantly more people than free institutional posts.
NMDA Receptor Ablation in Adolescent Mice Triggers Synaptic Rebound
Removing NMDA receptors in the adolescent mouse prefrontal cortex causes an initial spine loss followed by a compensatory synaptic rebound.
Plasma GFAP and NfL Predict Long-Term Mortality in Older Adults
Elevated baseline levels of GFAP and NfL strongly correlate with future risk of all-cause, dementia, and cardiovascular death.
Algorithm Predicts Parkinsonism Pathology From Clinical Symptoms
A machine learning tool trained on brain bank data uses 23 clinical parameters to accurately predict post-mortem pathology in parkinsonism.
Brain Imaging Maps How Deep Brain Stimulation Alters Parkinson's Circuits
Extensive functional MRI data from 14 patients reveals that cortical connectivity patterns can predict clinical outcomes of stimulation.
Social Isolation Linked to Mood Episodes in Youth Bipolar Disorder
A scoping review of 522 patients identifies loneliness as a marker of poor psychosocial function and altered neural social processing.
Decision Tool Reduces Antidepressant Discontinuation in Depression
A web-based system personalizing antidepressant selection kept more patients on therapy at 8 weeks and improved symptoms at 24 weeks.
Glutamate Levels Link to EEG Hyperexcitability in Borderline Personality Disorder
Metabolic imaging reveals that glutamate ratios in the nucleus accumbens and cingulate cortex correlate with neural instability markers.
Seven Hours of Sleep Maximizes Depression Risk Reduction in Older Adults
A national cross-sectional study reveals a non-linear relationship where the mental health benefits of sleep attenuate after seven hours.
ADHD Linked to Attenuated Rightward Structural Asymmetry in Children
MRI data reveal that reduced right-hemisphere dominance in frontal and striatal regions correlates with impaired attention and timing.
LGBTQ+ EMS Clinicians Balance Professional Identity and Disclosure
A qualitative analysis reveals how LGBTQ+ prehospital clinicians navigate workplace disclosure while prioritizing their clinical skills.
Sleep Under 6.7 Hours Linked to Depression in Opioid Users
A U-shaped dose-response curve reveals that insufficient sleep increases depression risk by 60% among adults taking prescription opioids.
Digital Dyadic Interventions Improve Cognition and Reduce Caregiver Burden
A review of 38 studies finds digital tools like mobile apps and remote platforms enhance patient cognition and ease caregiver burden.
Real-World CBT Improves Distress but Not Pain in Functional Neurological Disorder
Routine clinical data from 234 adults shows cognitive behavioral therapy significantly reduces psychological distress but not physical pain.
Social Skills Training Modulates Local Connectivity in the Autistic Social Brain
A 14-week intervention reduces regional homogeneity in the medial frontal gyrus, correlating with improved social responsiveness scores.
Paranoia and Distress Aversion Predict Faster Borderline Personality Disorder Response
Female patients with borderline personality disorder exhibiting higher baseline paranoia show faster symptom decline during residential care.