The Briefing · Psychiatry & Cognitive Neurology
Continuous newsroom coverage of evidence in Psychiatry & Cognitive Neurology — newest first.
LEAD STORY
Smoking Cessation Reduces Dementia Risk, But Weight Gain May Attenuate Benefit
A large prospective cohort study indicates quitting smoking lowers long-term dementia risk, though substantial post-cessation weight gain may…
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This week
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Neurobehavioral Profile of Young Steroid-Naive Boys With Duchenne Muscular Dystrophy
A multinational study characterizes baseline social, emotional, and learning challenges in young boys with Duchenne muscular dystrophy.
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Autoimmune Encephalitis Subtypes Identified in Rapidly Progressive Dementia
A multicenter study clarifies the prevalence and clinical presentations of specific autoimmune encephalitis subtypes in patients with rapidly progress
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Plantar Agraphesthesia Signals Lower Limb Cortical Sensory Loss in Corticobasal Syndrome
A case report details how plantar agraphesthesia can indicate cortical sensory deficits in the lower limb, even without hand involvement.
Earlier
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Maternal Microbial Exposure Confers Intergenerational Stress Resilience in Male Mouse Offspring
Maternal administration of a heat-killed bacterium protected male offspring from chronic stress effects, potentially via microbiome changes.
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VTA-mPFC Dopamine Circuit Drives Stress-Induced Sleep Fragmentation in Mice
A new study in mice identifies specific dopaminergic neuron hyperexcitability as a key mechanism behind chronic stress-related sleep disruption.
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Plasma p-tau217, Cognition, APOE4 Predict Alzheimer's Dementia Risk in SCD
A multimodal approach combining readily available biomarkers accurately identifies individuals with subjective cognitive decline at high risk for Alzh
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CBD's Pain Modulation Effects Vary by Opioid Dosing Timing in OUD Patients
A crossover study reveals cannabidiol's impact on pain sensitivity is dependent on whether opioid agonist treatment has been administered.
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Hippocampal Subfield Atrophy Links to Cognitive Decline in Healthy Aging
A study in healthy Indian adults identifies specific hippocampal subfield volume reductions in older age associated with poorer learning and memory.
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ITBS Improves Fibromyalgia Symptoms; D-Cycloserine Augments Depressive Symptoms Only
A randomized trial found intermittent theta-burst stimulation significantly reduced fibromyalgia symptoms, but adjunctive D-Cycloserine only…
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Astrocytic Enzyme Regulates Vascular Stability in Alzheimer's Disease Model
Targeting soluble epoxide hydrolase in astrocytes reduced vascular amyloid burden and preserved vasomotion in amyloidosis mice.
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Brainstem Circuit Mediates Slow-Wave Sleep's Anxiety Reduction
A specific GABAergic pathway from the parafacial zone to the ovBNST is identified as crucial for sleep-related anxiolysis.
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Physical Frailty Linked to Increased Epilepsy Incidence
A large prospective cohort study identifies physical frailty as an independent risk factor for developing epilepsy.
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Schizophrenia Spectrum Disorder Linked to Lower NSCLC Treatment Rates
A Japanese cohort study reveals patients with schizophrenia spectrum disorders receive less surgery and systemic therapy for non-small cell lung…
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Tau Aggregates Drive Neuronal Death via ZBP1 Activation in Tauopathies
A new study identifies a molecular cascade where tau aggregates reactivate transposable elements, leading to Z-RNA-ZBP1-mediated neuronal death.
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Weight Restoration Reverses Subcortical Limbic Changes in Anorexia Nervosa
Brain volume reductions in AN largely normalize with weight gain, linked to leptin, ghrelin, and neurofilament light changes.
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White Matter Microstructure Changes May Reflect Active Illness, Not Just Familial Risk
A large meta-analysis suggests that white matter abnormalities in schizophrenia and bipolar disorder are more tied to the disease process…
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Integrated Aesthetic Procedures Enhance Post-Mastectomy DIEP Flap Outcomes
A retrospective cohort study indicates that combining DIEP flap breast reconstruction with aesthetic procedures improves patient satisfaction.
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Contextual Fit Drives Physical Activity Program Success in Disadvantaged Schools
A review of 16 interventions identifies key implementation conditions for effective physical activity programs in socio-economically disadvantaged…
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Brain Connectivity Predicts Escitalopram Response in Depressed Adolescents
Specific resting-state functional connectivity patterns may identify adolescents with major depressive disorder who will respond to escitalopram.
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Retrosplenial Cortex Adapts History Integration for Flexible Decisions
Mouse study reveals how the retrosplenial cortex dynamically adjusts its processing of past experiences to support adaptive behavior.