Weight Restoration Reverses Subcortical Limbic Changes in Anorexia Nervosa

Anorexia nervosa (AN) remains a formidable clinical challenge, marked by high morbidity and mortality, particularly among young women [1, 2]. While neuroimaging has consistently shown that acute AN involves reductions in brain volume that often reverse with weight restoration, the precise neurobiology has been unclear [3, 4, 1]. Key questions have persisted regarding which specific brain structures are most affected, how completely they recover, and what biological mechanisms drive these changes [5]. A recent study provides a detailed map of these dynamic processes, linking structural brain recovery to specific hormonal and cellular markers.