CBD's Pain Modulation Effects Vary by Opioid Dosing Timing in OUD Patients
A crossover study reveals cannabidiol's impact on pain sensitivity is dependent on whether opioid agonist treatment has been administered.
ITBS Improves Fibromyalgia Symptoms; D-Cycloserine Augments Depressive Symptoms Only
A randomized trial found intermittent theta-burst stimulation significantly reduced fibromyalgia symptoms, but adjunctive D-Cycloserine only…
Weight Restoration Reverses Subcortical Limbic Changes in Anorexia Nervosa
Brain volume reductions in AN largely normalize with weight gain, linked to leptin, ghrelin, and neurofilament light changes.
Brain Connectivity Predicts Escitalopram Response in Depressed Adolescents
Specific resting-state functional connectivity patterns may identify adolescents with major depressive disorder who will respond to escitalopram.
Micropipette-Guided Administration Delivers Analgesics to Mouse Brains
A less invasive method for administering carprofen and buprenorphine in mice achieves therapeutic brain levels, particularly for buprenorphine.
Sternal Vibration Plus Mindfulness Improves Body Awareness, White Matter in Trauma
A study in trauma-exposed adults found sternal vibration combined with mindfulness meditation enhanced interoceptive awareness and increased neurite.
Simvastatin Rescues Cognitive Impairment in Alzheimer's Model via Epigenetic and Synaptic Pathways
A preclinical study in mice identifies specific molecular mechanisms by which simvastatin may improve cognitive function in Alzheimer's disease.
Fentanyl Differentially Modulates Dopamine Patterns, Impairing Reward Seeking in Mice
Acute fentanyl administration simultaneously increases tonic dopamine while reducing phasic dopamine responses to non-drug reward cues.
THC Disrupts Rat Fear Memory via Sex-Specific Microglial and Receptor Pathways
In male rats, THC requires microglial recruitment and dual receptor signaling, while female effects depend on the estrous cycle and CB1.
Sleep Efficiency Improvements Drive Antidepressant Response to CBT for Insomnia
A mechanistic trial shows that objective sleep gains, not changes in brain emotional circuits, correlate with improved mood symptoms.
Brain FAAH Levels Rise During Short-Term Cannabis Abstinence
PET imaging shows enzyme increases in the ventral striatum correlate with depression and impulsivity during early withdrawal.
Prenatal SRI Exposure Linked to Altered Fetal Brain and Placental Growth
MRI data show reduced hippocampal volume and cortical folding in fetuses exposed to antidepressants or high maternal depression scores.