Circulation
Randomized Controlled Trial
Memantine Reduces Premature Atrial Contractions and New-Onset Atrial Fibrillation
A phase 2 trial shows targeting cardiac N-methyl-D-aspartate receptors significantly lowers atrial ectopy and tachyarrhythmia burden.
Circulation
Registry Study
Fontan Registry Reveals High Comorbidity and Anxiety Rates in Adults
A multi-institutional study of 1,121 patients shows that nearly half of adults with Fontan circulation require treatment for anxiety.
Circulation
Animal Study
Gut Permeability Triggers Atrial Fibrillation via JNK2 Activation in Mice
Intestinal barrier dysfunction releases cytokines that activate cardiac JNK2, driving the calcium leaks that sustain atrial arrhythmias.
Circulation
Animal Study
Macrophage PRMT9 Limits Myocardial Infarction Damage in Mice
Researchers found that PRMT9 triggers STAT1 degradation to suppress inflammation and reduce infarct size in experimental models.
Circulation
Animal Study
Intestinal Permeability Triggers Atrial Fibrillation via JNK2 Activation in Mice
Researchers identified a signaling axis where leaky gut-associated cytokines activate cardiac JNK2 to cause calcium-handling abnormalities.