LANCETP launches 2025 guideline for Algorithmic Treatment of Schizophrenia
New international guidelines emphasize proactive metabolic health management from treatment initiation and earlier consideration of clozapine.
Heparin Dosing, ACT Monitoring Not Linked to Improved Outcomes After LEB
A large study suggests routine activated clotting time monitoring during lower extremity bypass may not improve patient outcomes.
HFpEF Patients Exhibit Higher Respiratory Muscle Oxygen Cost During Submaximal Exercise
A study reveals that individuals with heart failure with preserved ejection fraction expend significantly more oxygen for breathing during exertion.
Pediatric Burn Length of Stay Lower Than Traditional Benchmarks
A multi-institutional analysis of 1,543 pediatric burn patients updates expected hospital stay per TBSA, identifying key influencing factors.
Most Chronic Cough Patients Do Not Achieve Patient-Defined Control Post-Treatment
A single-center observational study established patient-anchored criteria for cough control, finding only 26% of patients met them.
Fibrin Binding Explains Reduced Circulating Myosin After Trauma
Direct binding of skeletal muscle myosin to fibrin clots may clarify its role in trauma-induced coagulopathy and observed plasma level changes.
Ibrutinib Response in WM Linked to Clonal Evolution, T-Cell Dynamics
A single-cell analysis reveals distinct tumor evolution patterns and immune cell changes predicting ibrutinib outcomes in Waldenström macroglobulinemi
Anti-C5a Antibody STSA-1002 Shows Favorable Safety, Reduced Mortality in ARDS
A phase 1b/2 trial indicates STSA-1002 is well tolerated and associated with lower 28-day mortality in viral pneumonia-induced ARDS.
ACEP launches 2025 clinical policy for Endotracheal Intubation in the Emergency Department
The new guideline prioritizes physiologic optimization, recommending noninvasive ventilation for preoxygenation and specific induction agents.
EUSEM launches 2025 guideline for Acute Pain Management in Emergency Situations
This updated guideline fundamentally shifts acute pain management in emergency settings towards multimodal, non-opioid first-line therapies.
ERC and ESICM launch 2025 guideline for Post-Resuscitation Care
New guidelines emphasize comprehensive diagnostic imaging, refined temperature control, and a multimodal approach to neurological prognostication.
AHA and ASA launch 2026 guideline for Acute Ischemic Stroke management
The new guideline introduces tenecteplase as an alternative to alteplase for IV thrombolysis and expands recommendations for pediatric stroke care.