Digoxin Reduces Heart Failure Risk in Rheumatic Heart Disease
A randomized trial in India shows low-dose digoxin decreases the composite risk of death or worsening heart failure by 18 percent.
Digitalis Reduces Worsening Heart Failure Events in Large Meta-Analysis
A study of 9,013 patients shows digitalis glycosides lower the risk of worsening heart failure events without affecting mortality.
Tirofiban Improves 90-Day Outcomes After Inadequate Tenecteplase Response
Adjunctive tirofiban increased the rate of functional independence in patients with non-large vessel stroke who failed to improve.
Antivirals and Birth-Dose Vaccines Reduce Hepatitis B Transmission and Cancer Risk
Comprehensive management of hepatitis B through early vaccination and targeted antiviral therapy can lower vertical transmission to under 1%.
Antiviral Therapy and Vaccination Strategies Reduce Hepatitis B Mortality
Comprehensive management using serologic markers and antivirals can halve the risk of hepatocellular carcinoma in chronic HBV patients.
Management Consultants Show No Benefit for Hospital Finances or Patient Outcomes
A study of 306 nonprofit hospitals found that $7.8 billion in consulting fees did not improve margins, operations, or clinical quality.
Evolocumab Reduces First Cardiovascular Events in High-Risk Diabetes
In patients with diabetes and no known atherosclerosis, adding evolocumab to statins lowered the 5-year risk of major events by 2.1%.
Cumulative Lead Exposure Linked to 3.5 Million Annual Cardiovascular Deaths
A meta-regression of NHANES data identifies bone lead levels as a major independent risk factor for global cardiovascular mortality.
Middle Meningeal Artery Embolization Reduces Subdural Hematoma Recurrence
Adjunctive embolization after surgery lowered symptomatic recurrence from 28% to 4.3% in a randomized trial of 186 patients.
Systematic Protocols Identify and Treat True Resistant Hypertension
True resistant hypertension affects 10% of treated patients and carries a 10.3% absolute risk increase in cardiovascular death.
Interdisciplinary Whole Health Teams Improve Chronic Pain Function Over Standard Care
A randomized trial of 764 veterans shows that value-aligned team care reduces pain interference more than group therapy or usual care.
Conduction System Pacing Reduces Hospitalization and Improves Ejection Fraction
New data suggest direct stimulation of the His bundle or left bundle branch improves outcomes over traditional biventricular pacing.