Opioid Medications Halve Mortality but Reach Only a Quarter of Patients
A clinical review details how optimizing methadone, buprenorphine, and naloxone can close the treatment gap and reduce all-cause mortality.
Tumor Debulking Adds Toxicity Without Survival Benefit in Metastatic Colorectal Cancer
Adding tumor debulking to chemotherapy fails to extend survival and increases severe adverse events in metastatic colorectal cancer.
Limiting ICU Wrist Restraints Fails to Increase Delirium-Free Days
A restrictive wrist-strap protocol in mechanically ventilated adults did not improve delirium-free days or increase self-extubation risk.
Structured Diagnostic Approach Guides Management of Chronic Diarrhea
A comprehensive clinical review details specific red flags for endoscopic evaluation and outlines empiric therapies that improve symptoms.
Decision Tool Reduces Antidepressant Discontinuation in Depression
A web-based system personalizing antidepressant selection kept more patients on therapy at 8 weeks and improved symptoms at 24 weeks.
Greater Than 10% Weight Loss Needed to Reduce Obesity-Linked Cancers
Observational data show bariatric surgery or GLP-1 agonists yield modest absolute risk reductions of 0.02% to 0.5% in cancer incidence.
Widening Hospital Margins Accelerate Oncology Biosimilar Adoption
As acquisition costs for cancer biosimilars drop faster than insurance reimbursements, hospitals are rapidly shifting to these therapies.