Remote Ischaemic Preconditioning Fails to Prevent Postoperative Myocardial Injury
A randomized trial of two-session preconditioning in abdominal surgery shows no reduction in injury and a paradoxical troponin increase.
Ketamine Does Not Reduce 28-Day Mortality Compared With Etomidate
A randomized trial of 2,365 critically ill adults found no survival benefit for ketamine, despite a higher rate of cardiovascular collapse.
LB-102 Reduces Acute Schizophrenia Symptoms in Phase 2 Trial
A randomized trial of the benzamide derivative LB-102 demonstrated significant PANSS score improvements across three daily dose levels.
Focal Coronary Disease Predicts Greater Angina Relief After Stenting
New ORBITA-2 data show focal lesions derive significantly more placebo-controlled benefit from PCI than diffuse disease patterns.
Nirmatrelvir-Ritonavir Fails to Reduce Hospitalization in Vaccinated Outpatients
Two randomized trials show no significant clinical benefit for high-risk adults with prior immunity from vaccination or infection.
Early Enteral Nutrition Reduces Complication Burden After Pancreatoduodenectomy
A randomized trial shows immediate tube feeding lowers the comprehensive complication index in patients at high nutritional risk.
Funnel-Shaped Mesh Reduces Parastomal Hernia Risk After Rectal Cancer Surgery
A randomized trial shows prophylactic mesh lowers three-year clinical hernia rates from 39% to 10% without increasing complications.
Dialectical Behavior Therapy and Schema Therapy Show Similar Efficacy for BPD
A 3-year randomized trial found no significant difference in symptom reduction or dropout between these two intensive psychotherapies.
Tucidinostat Improves Event-Free Survival in Double-Expressor B-Cell Lymphoma
Adding a histone deacetylase inhibitor to R-CHOP increases complete response rates and reduces progression risk in high-risk patients.
Tranexamic Acid Reduces Major Bleeding in Urologic Surgery
A randomized trial of 1,124 patients shows TXA reduces major bleeding by 3.4% without significantly increasing 30-day thrombotic risk.
Behavioral Nursing Model Improves Glycemic Control and Cognition in Older Diabetes Patients
A three-month Information-Motivation-Behavioral Skills intervention reduced HbA1c and psychological distress while improving cognitive scores.
Estradiol Patches Noninferior to LHRH Agonists in Prostate Cancer
A phase 3 trial shows transdermal estradiol maintains metastasis-free survival while reducing hot flashes in locally advanced disease.