Amoxicillin Equals Amoxicillin-Clavulanate for Acute Sinusitis
A nationwide cohort study shows standard amoxicillin is as effective as amoxicillin-clavulanate but avoids higher risks of C. difficile.
Serious Games Reduce Geriatric Trauma Undertriage in Nontrauma Centers
A randomized trial of 800 emergency physicians shows digital simulation training improves adherence to triage guidelines for older adults.
Endovascular Therapy Eases Post-Thrombotic Syndrome but Increases Bleeding
Iliac-vein stenting with enhanced antithrombotics improves symptoms and quality of life at six months, despite a higher bleeding risk.
Routine Prednisolone Does Not Prevent Coronary Lesions in Kawasaki Disease
A large randomized trial shows that adding steroids to standard therapy does not protect the coronary arteries of unselected children.
Zongertinib Drives High Response in First-Line HER2-Mutant Lung Cancer
The selective HER2 inhibitor achieved a 76% objective response rate and durable progression-free survival in treatment-naive patients.
Coping and Self-Efficacy Mediate Mood Improvements in Brain Tumor Caregivers
A secondary analysis of a randomized trial shows that a telehealth intervention reduces anxiety and depression by targeting specific psychological mec
Fecal Transplant Fails to Decolonize Resistant Bacteria in GI Disease
A randomized trial shows single-dose fecal microbiota transplant does not reduce multidrug-resistant organisms or resistance genes.
Chronotherapeutic Protocol Advances Circadian Timing and Extends Adolescent Sleep
A two-week intervention using light-modulating glasses and scheduling increased weeknight sleep by 47 minutes in high school students.
Asundexian Reduces Recurrent Stroke Without Increasing Major Bleeding
Adding the Factor XIa inhibitor asundexian to standard antiplatelet therapy safely lowers recurrent stroke risk in high-risk patients.
Genicular Artery Embolization Shows No Benefit Over Sham for Knee Osteoarthritis
A randomized trial finds that 12-month pain reduction after genicular artery embolization is statistically equivalent to a sham procedure.
High-Intensity tACS Improves Chronic Insomnia by Modulating Brain Networks
A randomized trial shows 15 mA stimulation reduces sleep index scores and reorganizes functional connectivity in hyperarousal circuits.
Lifestyle Intervention Benefits Cognition in Older Adults With Low Hippocampal Volume
A randomized trial shows intensive lifestyle coaching preserves cognition in high-risk patients despite unchanged brain biomarker trajectories.