2C-B Shows Empathogenic and Psychedelic Effects with Low Cardiovascular Strain
A crossover trial compares 30 mg of 2C-B to MDMA and psilocybin, finding similar emotional empathy and a shorter five-hour duration.
Semaglutide Improves Reward-Based Motivation in Patients With Major Depressive Disorder
A randomized trial shows oral semaglutide reduces the perceived cost of physical effort in patients with depression and elevated BMI.
Interdisciplinary Whole Health Teams Improve Chronic Pain Function Over Standard Care
A randomized trial of 764 veterans shows that value-aligned team care reduces pain interference more than group therapy or usual care.
Oral Factor D Inhibitor Fails to Improve Myasthenia Gravis Symptoms
A phase 2 trial of vemircopan was terminated after the oral complement inhibitor showed no significant benefit over placebo.
Pulsed Field Ablation Reduces Recurrence in Persistent Atrial Fibrillation
First-line pulsed field ablation showed a 56% success rate at 12 months compared to 30% for antiarrhythmic drugs in a randomized trial.
Mailed FIT-DNA Increases Colorectal Cancer Screening Rates in Community Health Centers
A pragmatic trial shows mailed FIT-DNA outreach achieves higher screening uptake than standard FIT, though follow-up colonoscopy rates remain low.
Videolaryngoscopy Increases First-Attempt Success for Double-Lumen Tube Intubation
A multicenter trial of 916 patients shows digital visualization improves glottic view and reduces esophageal intubation rates.
Online Therapist-Assisted Program Reduces Posttraumatic Stress in Injured Children
A randomized trial shows a digital cognitive behavioral intervention lowers symptom scores for six months following pediatric hospitalization.
Repeat OnabotulinumtoxinA for Masseter Prominence Does Not Alter Mandibular Bone
A 12-month placebo-controlled trial using CT imaging shows no significant bone remodeling after masseter injections for facial contouring.
Trabeculectomy Slows Visual Field Loss Better Than Medication in Advanced Glaucoma
A five-year trial shows surgery preserves monocular vision but finds no significant difference in patient-reported quality of life.
Symptom-Based Dosing Reduces Discharge Time in Neonatal Opioid Withdrawal
A cluster randomized trial shows symptom-based dosing shortens medical readiness for discharge when paired with the Eat, Sleep, Console model.
Proximal Nerve Stimulation Improves Sleep Apnea in CPAP-Intolerant Patients
A randomized trial shows proximal hypoglossal nerve stimulation significantly reduces apnea-hypopnea index and daytime sleepiness.