Individual LPFC Maps Reveal Fine-Grained, Interdigitated Networks

The human lateral prefrontal cortex (LPFC) is a cornerstone of complex cognition, orchestrating functions from executive control to decision-making [1, 2, 3, 4]. Consequently, dysfunction in this region is a common neurobiological feature across a spectrum of psychiatric and neurological conditions, including mood disorders, schizophrenia, and psychopathy [5, 6, 7]. While neuroimaging has advanced our understanding of brain networks, most insights into LPFC organization have relied on group-averaged data, which combines scans from many individuals and can smooth over fine-scale anatomical distinctions [8, 9]. A recent study using intensive, individual-focused imaging challenges this traditional approach, revealing a more intricate functional architecture that may better explain individual differences in cognition and disease.