The Briefing · Psychiatry & Cognitive Neurology
Continuous newsroom coverage of evidence in Psychiatry & Cognitive Neurology — newest first.
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LANCETP launches 2025 guideline for Algorithmic Treatment of Schizophrenia
New international guidelines emphasize proactive metabolic health management from treatment initiation and earlier consideration of clozapine.
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AA and SNMMI launch 2025 guideline for Amyloid and Tau PET Appropriate Use Criteria
New guidelines expand appropriate use of amyloid and tau PET, particularly for eligibility and monitoring of amyloid-targeting therapies.
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Alzheimer's Association launches 2024 guideline for Alzheimer's disease and related dementias
New guidance empowers primary care clinicians with a structured, patient-centered approach to diagnostic evaluation, testing, counseling.
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Global Efforts Advance Human Rights Protections for Older Adults' Mental Health
International bodies and national initiatives are establishing frameworks to safeguard the dignity and mental well-being of the aging population.
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Tea Polyphenols Mitigate Brain Changes, Anxiety in Aged Diabetic Rats
A preclinical study in aged T2DM rats suggests tea polyphenol intervention may improve hippocampal structure, function, and behavior.
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Diffuse White Matter Abnormalities Do Not Predict Long-Term Dementia Risk
A 10-year study finds that 'dirty-appearing' white matter lacks the prognostic weight of focal hyperintensities in older adults.
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Lamotrigine-Topiramate Duotherapy Increases Congenital Malformation Risk Fourfold
A large registry study identifies a significant risk increase for specific antiseizure drug combinations used during the first trimester.
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Biallelic EIPR1 Variants Cause Neurodevelopmental Syndrome and Neutropenia
Defects in endosomal recycling and dense core vesicle biogenesis drive a spectrum of microcephaly, ataxia, and spasticity.
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Hong Kong Genome Project Identifies Population-Specific Genetic Variants, Informs Prescriptions
A large-scale genomic initiative in the Chinese population reveals diagnostic rates for rare diseases and pharmacogenomic insights.
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Psychotherapy Benefits for Depression Persist for Years, Meta-analysis Shows
A comprehensive meta-analysis clarifies the long-term trajectory of psychotherapy's effectiveness for adult depression, showing sustained benefits.
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African Ancestry Parkinson’s Disease Linked to Distinct GBA1 and LRRK2 Variants
Genetic screening of 710 African ancestry cases reveals that common European risk variants are absent, replaced by population-specific mutations.
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Sternal Vibration Plus Mindfulness Improves Body Awareness, White Matter in Trauma
A study in trauma-exposed adults found sternal vibration combined with mindfulness meditation enhanced interoceptive awareness and increased neurite.
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Axonic Spines on Axon Initial Segment Initiate Action Potentials, Route Information
A new study in mice identifies axonic spines as a mechanism for precise action potential generation and directed neural circuit communication.
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Social Rank Modulates Empathic Pain via ACC-NAcC Circuit in Mice
A specific glutamatergic pathway and molecular target influence empathic pain responses based on social hierarchy.
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APOE ε2 and ε4 Drive Alzheimer's Risk Through Distinct Molecular Pathways
A multicohort proteomic analysis reveals allele-specific protein signatures influencing Alzheimer's disease risk and progression.
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CTBS to Right DLPFC Reduces Heavy Drinking Relapse Risk in AUD Over 12 Months
Continuous theta-burst stimulation to the right DLPFC lowered heavy-drinking relapse risk in AUD over 12 months in a randomized trial.
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SSRIs Induce Spatially Distinct Molecular Changes in Dorsal Raphe Serotonin Neurons
A mouse study reveals how fluoxetine alters gene expression and neuropeptide levels in specific serotonergic subpopulations.
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CANMAT and ICOCS launch 2025 international guideline for Obsessive-Compulsive Disorder
New joint guidelines establish a clear, tiered algorithm for OCD management, solidifying first-line options and defining evidence-based augmentation.
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Autism Subtypes Linked to Distinct Brain Connectivity and Biological Pathways
A cross-species neuroimaging study identifies two replicable autism subtypes with specific functional connectivity patterns and biological underpinnin
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Simvastatin Rescues Cognitive Impairment in Alzheimer's Model via Epigenetic and Synaptic Pathways
A preclinical study in mice identifies specific molecular mechanisms by which simvastatin may improve cognitive function in Alzheimer's disease.
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Somatic Symptoms, Sensory Dysregulation Are Core to PTSD Presentation
Current PTSD treatments often fall short because they overlook the central role of physical sensations and sensory processing.
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ED Nudge Strategy Increases Naltrexone Prescribing for Alcohol Misuse
A multicomponent emergency department protocol significantly raised naltrexone initiation for patients with alcohol-related diagnoses.
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Demographics Influence Etiology in 2,052 Patients With Late-Onset Seizures
A multicenter study finds that while stroke remains common, neurodegeneration and unexplained causes dominate the geriatric epilepsy profile.
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Selective HDAC6 Inhibition Improves Motor Function in Preclinical ALS Models
A CNS-penetrant small molecule restores protein clearance and axonal transport, reducing neurofilament levels and TDP-43 pathology.