Trial Watch · Psychiatry & Cognitive Neurology
Clinical trials in Psychiatry & Cognitive Neurology, ranked by methodological rigor and ordered by most recent.
Multimodal AI System Matches Clinicians in Simulated Telehealth Diagnostics
A new AI system, multimodal AMIE, integrates diverse data types to achieve high diagnostic accuracy and conversational quality in simulated telehealth
Randomized Controlled Trial
2C-B Shows Empathogenic and Psychedelic Effects with Low Cardiovascular Strain
A crossover trial compares 30 mg of 2C-B to MDMA and psilocybin, finding similar emotional empathy and a shorter five-hour duration.
Randomized Controlled Trial
Interdisciplinary Whole Health Teams Improve Chronic Pain Function Over Standard Care
A randomized trial of 764 veterans shows that value-aligned team care reduces pain interference more than group therapy or usual care.
Randomized Controlled Trial
Semaglutide Improves Reward-Based Motivation in Patients With Major Depressive Disorder
A randomized trial shows oral semaglutide reduces the perceived cost of physical effort in patients with depression and elevated BMI.
Randomized Controlled Trial
Online Therapist-Assisted Program Reduces Posttraumatic Stress in Injured Children
A randomized trial shows a digital cognitive behavioral intervention lowers symptom scores for six months following pediatric hospitalization.
Randomized Controlled Trial
Symptom-Based Dosing Reduces Discharge Time in Neonatal Opioid Withdrawal
A cluster randomized trial shows symptom-based dosing shortens medical readiness for discharge when paired with the Eat, Sleep, Console model.
Randomized Controlled Trial
Luvadaxistat Fails to Improve Schizophrenia Cognition in Phase 2 Trial
The ERUDITE study found no significant cognitive benefit from adding the D-amino acid oxidase inhibitor to stable antipsychotic therapy.
Randomized Controlled Trial
Physical Therapy Improves Function More Than CBT in Chronic Low Back Pain
A sequential randomized trial finds physical therapy superior for initial functional gains, though secondary strategies show no difference.
Randomized Controlled Trial
Counterconditioning Stabilizes Neural Safety Signals in PTSD
Functional MRI shows pairing threat stimuli with positive outcomes reinforces safety patterns in the ventromedial prefrontal cortex.
Non-Randomized Controlled Trial
Pitch Gestures Increase Prefrontal Activation During Mandarin Tone Sandhi Perception
Training with physical gestures strengthens functional connectivity in the left dorsolateral prefrontal cortex to improve auditory discrimination.
Randomized Controlled Trial
LB-102 Reduces Acute Schizophrenia Symptoms in Phase 2 Trial
A randomized trial of the benzamide derivative LB-102 demonstrated significant PANSS score improvements across three daily dose levels.
Non-Randomized Controlled Trial
Telepractice PTR-F Improves Parent Fidelity in Chinese American Families
A culturally adapted behavioral intervention delivered remotely increased parent adherence and reduced challenging behaviors in autistic children.
Randomized Controlled Trial
Dialectical Behavior Therapy and Schema Therapy Show Similar Efficacy for BPD
A 3-year randomized trial found no significant difference in symptom reduction or dropout between these two intensive psychotherapies.
Randomized Controlled Trial
Behavioral Nursing Model Improves Glycemic Control and Cognition in Older Diabetes Patients
A three-month Information-Motivation-Behavioral Skills intervention reduced HbA1c and psychological distress while improving cognitive scores.
Randomized Controlled Trial
Baseline Connectivity Predicts Anxiety Improvement in Prefrontal TMS Trial
Pre-treatment neural architecture, rather than post-stimulation connectivity changes, correlates with clinical recovery in patients.
Randomized Controlled Trial
Coping and Self-Efficacy Mediate Mood Improvements in Brain Tumor Caregivers
A secondary analysis of a randomized trial shows that a telehealth intervention reduces anxiety and depression by targeting specific psychological mec
Randomized Controlled Trial
Chronotherapeutic Protocol Advances Circadian Timing and Extends Adolescent Sleep
A two-week intervention using light-modulating glasses and scheduling increased weeknight sleep by 47 minutes in high school students.
Randomized Controlled Trial
High-Intensity tACS Improves Chronic Insomnia by Modulating Brain Networks
A randomized trial shows 15 mA stimulation reduces sleep index scores and reorganizes functional connectivity in hyperarousal circuits.
Randomized Controlled Trial
Apps for Alcohol Use Do Not Improve Mood Beyond Standard Care
In a randomized trial, digital tools added to standard care did not further reduce depression or anxiety in adults with alcohol dependence.
Non-Randomized Controlled Trial
Structured Exercise Improves Sleep and Executive Function in Preteens With Autism
A 10-to-12-week physical activity program objectively reduced sleep fragmentation and improved problem-solving in children with autism.
Randomized Controlled Trial
Web-Based School Program Reduces New-Onset Mental Health Problems
An eight-session internet intervention focused on stress management lowered the one-year incidence of mental health issues from 28% to 21%.
Randomized Controlled Trial
Decision Tool Reduces Antidepressant Discontinuation in Depression
A web-based system personalizing antidepressant selection kept more patients on therapy at 8 weeks and improved symptoms at 24 weeks.
Non-Randomized Controlled Trial
Social Skills Training Modulates Local Connectivity in the Autistic Social Brain
A 14-week intervention reduces regional homogeneity in the medial frontal gyrus, correlating with improved social responsiveness scores.
Randomized Controlled Trial
Hybrid Dialectical Behavior Therapy Reduces Suicidal Ideation in Adolescents
A year-long trial shows combining online and offline DBT improves emotional regulation and depressive symptoms in self-injuring youth.
Randomized Controlled Trial
Clozapine Increases Response After One Failed Antipsychotic in Early Psychosis
A sequential trial reveals that switching to clozapine after a single failed antipsychotic yields a 62.5% response rate in early psychosis.