American Journal of Psychiatry
Randomized Controlled Trial
Low-Dose Buprenorphine Sustains Ketamine's Antisuicidal Effects in MDD
A randomized trial indicates sublingual buprenorphine extends ketamine's rapid reduction of suicidal ideation in major depressive disorder.
American Journal of Psychiatry
Randomized Controlled Trial
Magnetic Seizure Therapy Limits Memory Loss in Bipolar Depression Trial
A randomized pilot study shows magnetic seizure therapy matches the efficacy of ultrabrief ECT while reducing cognitive adverse effects.
American Journal of Psychiatry
In Vitro Study
Transcriptional Map Identifies 37 Interneuron Subtypes in Human Prefrontal Cortex
Researchers used single-nucleus RNA sequencing to define molecular signatures of somatostatin and parvalbumin cells in healthy adults.
American Journal of Psychiatry
Meta-Analysis
Bitemporal ECT and rTMS Plus SSRIs Reduce Suicidal Ideation
A network meta-analysis of 58 trials finds nonconvulsive brain stimulation alone is ineffective for suicidal ideation without medication.
American Journal of Psychiatry
Consensus Statement
Experts Recommend Lithium and Antidepressants to Prevent ECT Relapse
A Delphi consensus of international experts outlines structured maintenance therapies, including continuation ECT for high-risk patients.