Epilepsy Patients Show Amyloid-Independent Tau Deposition Linked to Clinical Severity
PET imaging and proteomics reveal that chronic epilepsy correlates with widespread tau accumulation and accelerated multi-organ aging.
Guillain-Barré Syndrome Incidence Declined 9% in Japan During the Pandemic
A nationwide survey reveals a shift toward demyelinating subtypes and older patients as conventional infectious triggers decreased.
DMN Connectivity Predicts Amyloid Accumulation and Clinical Decline in Alzheimer’s
Longitudinal imaging shows functional network disruptions precede detectable amyloid plaques and signal future cognitive impairment.
GABAA Gain-of-Function Mutation Triggers Seizures via Interneuron Network Collapse in Mice
A study of the GABRB3 p.(Glu77Lys) variant reveals how enhanced inhibitory signaling paradoxically drives cortical hyperexcitability.
Eleven-Protein Plasma Panel Identifies Parkinson’s Disease Across Four Cohorts
A machine learning model using 11 plasma proteins differentiated Parkinson’s from other neurological conditions with high accuracy.
Lower Tau PET Sensitivity in Older Men Reflects Reduced Tangle Density
Flortaucipir PET sensitivity for advanced Alzheimer pathology drops to 42% in patients over 83, mirroring lower biological tangle burdens.
Glial GLRX3 Enzyme Drives Chronic Oxaliplatin-Induced Pain in Aged Models
A redox circuit in the dorsal root ganglion identifies potential biomarkers and therapeutic targets for age-related chemotherapy toxicity.