Exogenous Hormones Associate With Reduced Dementia Risk in UK Biobank Cohort
Use of oral contraceptives and hormone replacement therapy correlates with lower rates of Alzheimer's disease and vascular dementia.
Clinical Criteria for LATE Distinguish Cognitive Trajectories from Alzheimer Disease
A study of 3,606 patients shows isolated LATE progresses slower than Alzheimer disease, while comorbid pathology accelerates decline.
Distinct Cortical Thickness Patterns Define Positive and Negative Schizotypy
MRI analysis of 2730 healthy adults links subclinical traits to specific neurotransmitter systems and neurodevelopmental disorders.
Ceruloplasmin Deficiency Linked to Fusiform Gyrus Pathology in Autism Subtype
Low ceruloplasmin levels drive lipid and myelin imbalances in children with autism and atypical visual processing.
Apixaban Reduces Recurrent Stroke in Patients Without High-Risk Hypertension
An ARCADIA trial analysis shows apixaban is more effective than aspirin only when severe hypertension and cardiac hypertrophy are absent.
Cannabis Use Blunts Neurocognitive Development in Adolescents
Longitudinal data and hair toxicology link THC exposure to flattened growth in memory and processing speed from ages 9 to 17.
One in Four Non-Comatose Cardiac Arrest Survivors Face Poor Outcomes
A registry analysis identifies age, motor response, and pH levels as key predictors of 30-day recovery in patients who avoid post-arrest coma.
Increased Tibial Slope Raises Risk of Meniscal Allograft Failure
A retrospective cohort study finds higher posterior tibial slope correlates with reoperation and failure despite stable functional scores.
Lower Tau PET Sensitivity in Older Men Reflects Reduced Tangle Density
Flortaucipir PET sensitivity for advanced Alzheimer pathology drops to 42% in patients over 83, mirroring lower biological tangle burdens.
One Quarter of Helicopter Emergency Missions Provide No Clinical Benefit
A retrospective analysis of 2,286 missions shows that while 74 percent are beneficial, many deployments lack clear utility.
Clinical Pathway Cuts Pediatric CT Use and Emergency Department Wait Times
A multidisciplinary protocol prioritizing ultrasound and surgical consultation met national quality goals while reducing stay by 103 minutes.
Sex Not Independently Linked to Post-Arrest Neurological Recovery
Observed survival disparities between men and women disappear after adjusting for initial rhythm and arrest etiology.