Danish Registry Data Show Rising ADHD Medication Use and Sex Convergence
Prevalence tripled among girls between 2010 and 2023, though they continue to initiate treatment two years later than boys.
Pediatric Knife Fatalities Linked to Deprivation and Prior Social Service Contact
A five-year review of 145 deaths in England identifies high rates of pre-hospital mortality and significant psychosocial vulnerabilities.
Pre-Diagnosis FEV1 Decline Predicts Mortality in Lung Transplant Recipients
A 20-year cohort study shows that the rate of lung function loss before CLAD onset identifies patients at high risk for rapid progression.
Valproate Linked to Higher Mortality in Patients With Dementia and Epilepsy
A Swedish registry study finds lamotrigine and levetiracetam associated with better survival than valproate or carbamazepine.
Vascular Comorbidities Double Mortality Risk in Haploidentical Transplants
A machine-learning analysis identifies a vascular penalty and a three-factor tool to optimize donor selection in allogeneic HCT.
Routine ICU Delirium Screening Misses 72% of Cases in Spanish Speakers
Caregiver-administered assessments can recover nearly half of missed delirium diagnoses when patient-provider language barriers exist.
Ambulance Lights and Sirens Save Only Three Minutes During Patient Transport
A study of 25,902 incidents suggests the modest time savings of emergent transport may not justify the tripled risk of collisions.
GNAO1-Related Disorders Follow Non-Degenerative Course Despite Progressive Movement Symptoms
A longitudinal study of 66 patients shows cognitive stability while severe cases face functional burden from worsening movement disorders.
TTVR Eliminates Severe Tricuspid Regurgitation in Real-World Registry
A US registry study of 1,034 patients shows 98% procedural success and significant functional gains with low 30-day mortality.
MTOR Hyperactivation Suppresses Autophagy and Drives Neuroinflammation in Schizophrenia
Restoring cellular waste clearance via mTOR inhibition reduces pro-inflammatory cytokines and glial activation in schizophrenia models.
Silent Urate Deposits Found in 39% of Asymptomatic Hyperuricemia Patients
Standardized ultrasound reveals subclinical crystal deposition is linked to early joint erosion and synovial inflammation before the first gout flare.
Glial GLRX3 Enzyme Drives Chronic Oxaliplatin-Induced Pain in Aged Models
A redox circuit in the dorsal root ganglion identifies potential biomarkers and therapeutic targets for age-related chemotherapy toxicity.