Tranexamic Acid Efficacy Varies by Breast Procedure Type
A retrospective cohort study clarifies which breast surgeries benefit from tranexamic acid for hematoma prevention.
Chronic Pain Mechanisms Show Distinct Cortical Connectivity Patterns
A study using TMS-EEG identifies neurophysiological differences across nociceptive, neuropathic, and nociplastic pain phenotypes.
THA Approaches Yield Similar Patient Outcomes, Distinct Gait Biomechanics
While patient-reported improvements are consistent across THA approaches, minimally invasive techniques offer specific early gait efficiency.
TMEM106B Variant Delays FTD Onset in GRN Mutation Carriers
A specific genetic variant significantly reduces FTD onset risk and extends median onset age by 14 years in GRN mutation carriers.
Male Facelift Hematoma Rates Similar to Females With Standardized Protocols
A matched cohort analysis indicates that male facelift patients experience comparable hematoma rates to females when modern surgical protocols.
Acquired Anosmia Affects Quality of Life More Than Congenital Anosmia
A study of 59 patients reveals how the origin and duration of anosmia influence perceived impairment and coping.
ICU Readmission Increases 60-Day Mortality Regardless of Frailty Status
A large registry study finds frail, readmitted patients face the highest mortality, but frailty does not alter readmission's incremental risk.
Genetic Maps Reveal Psychiatric Disorder Clusters, Clinical Feature Links
A Swedish register study maps genetic risk for 12 disorders, showing how liabilities vary with sex, onset age, and recurrence.
PU.1 Activation Identifies Low-Risk MDS Patients at High Progression Risk
A molecular signature involving PU.1 genomic occupancy distinguishes a subset of low-risk MDS patients prone to progression and reduced survival.
Periventricular Lesions Drive Cognitive Decline by Disrupting Cholinergic Pathways in Parkinson's
White matter injury triggers cortical terminal loss and retrograde atrophy, identifying a structural biomarker for cognitive risk.
PET Imaging Tracks Metabolic Decline Across ALS Clinical Stages
A large cohort study links King's staging to progressive loss of brain connectivity and transient cerebellar recruitment in ALS.
Tezepelumab Reduces Exacerbations, Improves Lung Function in Diverse Severe Asthma Cohort
A real-world phase 4 study shows tezepelumab's effectiveness and safety across various severe asthma phenotypes and underrepresented patient groups.