VWF Deficiency Drives Angiodysplasia via Angiopoietin-2 Dysregulation
New research identifies a molecular pathway linking von Willebrand factor deficiency to gut angiodysplasia, suggesting a targeted therapeutic…
New Imaging Reveals Hippocampal Dendrite Signaling Dynamics In Vivo
A novel 3D motion-corrected imaging platform allows direct observation of electrical and calcium activity in live neuronal dendrites.
ATF2 Phosphorylation Drives Neuronal Apoptosis in Neurodegenerative Disease Models
A genome-wide screen identifies a specific molecular cascade involving ATF2 phosphorylation as a core driver of neuronal cell death.
TP53 and 5q Deletion Drive AML-CK Aneuploidy, Create BCL2 Vulnerability
A new study identifies the genetic drivers of complex karyotype acute myeloid leukemia and a targetable BCL2-dependent vulnerability.
Stem Cell Dynamics Link to Epigenetic Aging Across Mammals
A new mathematical model connects stem cell activity to age-related DNA methylation patterns, offering a unified explanation for biological aging.
MIF Modulates Astrocyte Distribution in Schizophrenia Cortical Spheroids
A new study using patient-derived brain models identifies macrophage migration inhibitory factor (MIF) as a key regulator of astrocyte function.
Low-Dose IL-2 Fails to Expand Tregs After Alemtuzumab in RRMS
A mechanistic study reveals that low-dose interleukin-2 alone does not boost regulatory T cells in alemtuzumab-treated multiple sclerosis patients.
MSC-Exos Restore Hippocampal Neuron Morphology After Stress via Wnt5a Pathway
Mesenchymal stem cell-derived exosomes mitigate stress-induced morphological deficits in hippocampal neurons through a specific signaling pathway.
DHODH Inhibition Targets Pyrimidine Synthesis in Chemo-Resistant B-ALL
A new study identifies dihydroorotate dehydrogenase (DHODH) as a metabolic vulnerability in B-ALL cells with active signaling.
Acetate Attenuates Microglial Inflammation in Traumatic Brain Injury Model, Not Sepsis
Physiological doses of the gut metabolite acetate reduced inflammatory markers in an in vitro TBI model, but not in a sepsis model.
CircPCMTD1 Peptide Regulates DNA Damage Response in BCR/ABL1-Positive Leukemias
A newly characterized circular RNA and its peptide product modulate genotoxic stress tolerance, offering a potential therapeutic target.
PSMD1 Inhibition via LNPs Reduces Myeloma Growth, Overcomes Resistance
Targeting the proteasome subunit PSMD1 with siRNA delivered by lipid nanoparticles shows efficacy in multiple myeloma models.