Algorithm Predicts Parkinsonism Pathology From Clinical Symptoms
A machine learning tool trained on brain bank data uses 23 clinical parameters to accurately predict post-mortem pathology in parkinsonism.
Inhibiting USP22 Halts Periodontitis-Linked Brain Inflammation in Mice
Knocking down the enzyme USP22 in mice prevents the periodontal pathogen P. gingivalis from degrading blood-brain barrier tight junctions.
Women Face Worse Functional Recovery After Intensive Care EEG
Despite similar acute management and mortality, critically ill women are half as likely as men to achieve favorable long-term recovery.
Baseline Breathing Patterns Predict Post-Seizure Hypoxemia Severity
Measuring respiratory variability between seizures may help identify epilepsy patients at highest risk for severe oxygen desaturation.
Brain Imaging Maps How Deep Brain Stimulation Alters Parkinson's Circuits
Extensive functional MRI data from 14 patients reveals that cortical connectivity patterns can predict clinical outcomes of stimulation.
Structured Diagnostic Approach Guides Management of Chronic Diarrhea
A comprehensive clinical review details specific red flags for endoscopic evaluation and outlines empiric therapies that improve symptoms.
Social Isolation Linked to Mood Episodes in Youth Bipolar Disorder
A scoping review of 522 patients identifies loneliness as a marker of poor psychosocial function and altered neural social processing.
Decision Tool Reduces Antidepressant Discontinuation in Depression
A web-based system personalizing antidepressant selection kept more patients on therapy at 8 weeks and improved symptoms at 24 weeks.
Glutamate Levels Link to EEG Hyperexcitability in Borderline Personality Disorder
Metabolic imaging reveals that glutamate ratios in the nucleus accumbens and cingulate cortex correlate with neural instability markers.
Obinutuzumab Shows High Efficacy in Active Systemic Lupus Erythematosus
A phase 3 trial shows the anti-CD20 antibody obinutuzumab significantly improves clinical responses and reduces flares in active lupus.
Pimicotinib Yields 54% Response in Tenosynovial Giant Cell Tumors
The selective inhibitor pimicotinib demonstrates high efficacy for unresectable joint tumors while avoiding severe hepatotoxicity.
Zorevunersen Cuts Convulsive Seizures in Children With Dravet Syndrome
The investigational antisense therapy reduced convulsive-seizure frequency by up to 90.91% and improved adaptive behavior over 36 months.