Cerebellar Disinhibitory Circuit Controls Motor Learning Signals
New research in mice reveals how synchronized climbing fiber activity selectively gates error signals to enable adaptive motor learning.
Ensitrelvir Reduces COVID-19 Incidence by 6.1% in Household Contacts
An oral SARS-CoV-2 3C-like protease inhibitor significantly lowers infection rates when given as postexposure prophylaxis.
Secreted GPNMB Drives Alpha-Synuclein Spread in Parkinson's Disease
A new study identifies a microglial-neuronal feedback loop involving GPNMB that exacerbates alpha-synuclein pathology, offering a therapeutic target.
Daratumumab-VCd Improves Survival, Organ Function in AL Amyloidosis
Final ANDROMEDA analysis confirms sustained benefits of D-VCd for newly diagnosed light-chain amyloidosis, including overall survival.
Skin Biopsy Distinguishes Body-First from Brain-First Parkinson’s Disease
Cutaneous alpha-synuclein signatures and seeding activity identify divergent pathological origins and autonomic denervation patterns.
TES Criteria Show Low Accuracy for CTE-NC Diagnosis
A study of 1,038 brain bank cases reveals that traumatic encephalopathy syndrome criteria poorly predict postmortem chronic traumatic encephalopathy.
Critically Ill Women in India Receive Less Organ Support, Show Similar Mortality
A large registry-embedded cohort study reveals sex-based differences in critical care provision without impacting adjusted mortality.
Indian ICUs: Women Receive Less Organ Support, Similar Mortality to Men
A large registry-embedded cohort study in India reveals sex-based differences in critical care resource utilization.
Gram-Negative Bacteria Dominate Neonatal Infection Deaths in LMICs
A multicountry study identifies Klebsiella pneumoniae and Acinetobacter baumannii as leading causes of neonatal infection mortality.
Intracranial Stimulation Prevents Attentional Lapses in Children
A new study identifies a real-time neural signature for attentional control, enabling targeted intervention to improve attention shifts.
Recent Trauma Exposure Linked to Increased V1 Thickness, Independent of PTSD Symptoms
A two-sample study identifies greater V1 thickness in recently trauma-exposed individuals, a finding distinct from PTSD symptom severity.
Tfr2 Essential for Acute Hepcidin Induction in Tfr1-Deficient Mouse Hepatocytes
A murine study reveals that transferrin receptor 2 and HFE must cooperate to trigger hepcidin during rapid iron fluctuations.