Postpartum Psychosis Heritability Estimated, Specific Risk Genes Identified
New research quantifies genetic contributions to postpartum psychosis and identifies specific genes, including shared pathways with other psychiatric
High-Impact Sports Linked to 4-15-Fold Increased MND/ALS Risk
A scoping review identifies a significant association between professional participation in high-impact sports and elevated motor neurone disease risk
Neuroimaging Biotypes May Guide MDD Treatment, Improve Remission
Functional MRI-derived circuit profiles could personalize major depressive disorder therapy, potentially doubling remission rates.
NPM1-Mutated AML: Nuclear Condensates Drive HOX/MEIS1 Expression, Inform Menin Inhibitor Action
New research clarifies how mutant NPM1 forms nuclear condensates, sustaining oncogenic transcription and explaining menin inhibitor efficacy.
Apelin Mediates Exercise's Antidepressant Effects via Hippocampal NMDA Receptors
A muscle-derived protein, apelin, links physical activity to improved mood and neuroplasticity through a specific brain signaling pathway.
Specific Patient Profiles Face Up to 30% Risk of Severe Asthma Progression
A large Danish cohort study identifies key risk factors and patient characteristics associated with progression from mild-to-moderate to severe asthma
Three Genetic Loci Modify Risk and Onset of Inherited Alzheimer's Disease
Specific genetic variants influence disease risk and age of dementia onset in autosomal dominant Alzheimer's disease.
Bupivacaine-Dexamethasone TAP Blocks Reduce LOS, Opioid Use in DIEP Flap Patients
A retrospective study suggests bupivacaine with dexamethasone improves early pain control and shortens hospital stay after DIEP flap breast reconstruc
Fentanyl Differentially Modulates Dopamine Patterns, Impairing Reward Seeking in Mice
Acute fentanyl administration simultaneously increases tonic dopamine while reducing phasic dopamine responses to non-drug reward cues.
ICU Caregiver Financial Strain Linked to Psychological Distress, Medical Mistrust
A study of 97 ICU caregivers found that over 60% reported difficulty paying for care, correlating with increased anxiety, depression, PTSD, and decisi
Expert Consensus Standardizes SSA/Ro Autoantibody Nomenclature
A Delphi process involving 17 international experts recommends specific terms for anti-TROVE2/Ro60 and anti-TRIM21/Ro52 autoantibodies.
Abatacept Reduces Rheumatoid Arthritis Progression in Seropositive Palindromic Rheumatism
A randomized trial indicates abatacept significantly lowers the risk of developing rheumatoid arthritis compared to hydroxychloroquine over two years.