Intravenous Magnesium Sulfate Reduces Rescue Analgesia for Acute Headache
A randomized trial finds adjunctive magnesium sulfate increases treatment success and patient satisfaction, despite pain reduction not meeting clinica
Multimodal AI System Matches Clinicians in Simulated Telehealth Diagnostics
A new AI system, multimodal AMIE, integrates diverse data types to achieve high diagnostic accuracy and conversational quality in simulated telehealth
ALS Subtypes Show Distinct Immune Remodeling, Linking Blood Changes to Spinal Cord Damage
A new study details specific immune cell dynamics and molecular programs in ALS, revealing distinct patterns across disease subtypes.
Thrombectomy Improves Functional Independence in Medium-Vessel Occlusion Stroke
A randomized trial shows endovascular thrombectomy increases functional independence but also raises symptomatic intracranial hemorrhage risk in mediu
SHANK3 Haploinsufficiency in Macaques Reveals Diverse Behavioral, Cognitive Phenotypes
A new macaque model of SHANK3 haploinsufficiency provides insights into Phelan-McDermid syndrome and potential biomarkers.
SSPOP Mutations Linked to Pediatric Epilepsy and Developmental Disorders
Researchers identify pathogenic variants in a supposed pseudogene, expanding the diagnostic landscape for unexplained neurodevelopmental delay.
Long-Duration Levodopa Response Distinguishes Parkinson's, Predicts Outcomes
A study details how sustained levodopa motor improvement helps differentiate parkinsonian syndromes and offers prognostic insights for PD.
Gender-Affirming Mastectomy Linked to Sustained Satisfaction, Quality of Life
A cross-sectional study finds high patient-reported chest satisfaction and psychological well-being years after gender-affirming mastectomy.
Alantolactone and Temozolomide Combination Targets Glioblastoma Stemness, Lipid Metabolism
Preclinical findings suggest alantolactone combined with temozolomide may overcome glioblastoma resistance by modulating the Hippo pathway.
Digital and Mixed Interventions Support Physical Activity After Exercise Therapy
An umbrella review suggests digital and mixed delivery methods help patients with chronic conditions maintain physical activity and quality of life.
Postpartum Psychosis Heritability Estimated, Specific Risk Genes Identified
New research quantifies genetic contributions to postpartum psychosis and identifies specific genes, including shared pathways with other psychiatric
High-Impact Sports Linked to 4-15-Fold Increased MND/ALS Risk
A scoping review identifies a significant association between professional participation in high-impact sports and elevated motor neurone disease risk