Prefrontal Gene Networks Predict Fentanyl Escalation in Rat Models
Researchers identified specific ion channel and synaptic signaling pathways in the prefrontal cortex linked to compulsive opioid intake.
Chilean Pediatric Type 1 Diabetes Incidence Doubled Since 2007
A nationwide study shows a pandemic-era surge in new cases and diabetic ketoacidosis before a return to historical trends in 2022.
Cardiac Arrest Increases Mortality and Coronary Complexity in STEMI Shock
A retrospective study of 345 patients shows that cardiac arrest in cardiogenic shock signals higher SYNTAX scores and 80% 1-year mortality.
Four Distinct Internet Addiction Profiles Identified in Nursing Students
Latent profile analysis reveals that health-related problems and withdrawal symptoms drive severity in high-risk student groups.
Prior Tibial Osteotomy Increases Revision Risk After Conversion Knee Arthroplasty
A national database study finds higher rates of stiffness and revision in younger patients transitioning from osteotomy to total knee replacement.
Hospital and Surgeon Culture Drive Extended-Release Opioid Use After Arthroplasty
A study of 229,995 joint replacements shows institutional patterns, not patient factors, primarily dictate postoperative long-acting opioid dispensing
Physician-Led Program Improves Prehospital Care for Medically Complex Children
The STARS initiative uses individualized electronic care plans and targeted EMS training to reduce unnecessary hospital transports.
Childhood Trauma Linked to Altered Mitochondrial Bioenergetics in Adults
Adults with early life adversity show increased mitochondrial respiratory capacity and reduced glycolytic ATP production in immune cells.
Donor-Derived Anti-CD33 CAR T-Cells Show Safety in Relapsed AML Post-Transplant
A phase 1/2 trial of VCAR33 demonstrates manageable toxicity and preliminary activity in patients with relapsed or MRD-positive disease.
Preoperative Antifibrinolytics Reduce Transfusions After Vascular Surgery
A multi-hospital study finds early administration of tranexamic acid or epsilon-aminocaproic acid lowers transfusion needs by 43 percent.
Creative Adolescents Show Higher Neural Synchrony During Complex Film Viewing
Functional MRI data reveal that highly creative youth exhibit unique attentional alignment when processing non-linear cinematic montage.
Training-Free AI Framework Automates Radiographic Morphometry Across Multiple Joints
A generalist landmark matching model achieves measurement accuracy comparable to radiologists without requiring anatomy-specific datasets.