Tucidinostat Improves Event-Free Survival in Double-Expressor B-Cell Lymphoma
Adding a histone deacetylase inhibitor to R-CHOP increases complete response rates and reduces progression risk in high-risk patients.
Telepractice PTR-F Improves Parent Fidelity in Chinese American Families
A culturally adapted behavioral intervention delivered remotely increased parent adherence and reduced challenging behaviors in autistic children.
Clinical and Social Markers Predict Six-Month Alcohol Abstinence
A multivariate analysis of 152 patients identifies treatment completion and organ damage as key indicators of long-term recovery.
Quality of Life Buffers Adolescent Risk Behaviors in Configurational Analysis
A study of 560 students identifies specific combinations of depression and alcohol use that drive high-risk clinical profiles.
Serum sRAGE Levels Link Biological Rhythm Stability to Depression Severity
A case-control study identifies soluble RAGE as a protective mediator against circadian disruption and insomnia in depressed patients.
U-Shaped Sleep Duration Linked to Depression in Postmenopausal Women
Analysis of 4,891 women identifies 7.5 hours as the inflection point where both short and long sleep correlate with symptom severity.
Executive Inhibition Deficits Moderate Startle Response in Trauma-Exposed Adults
Poorer cognitive control interacts with physiological hyperarousal to increase the severity of PTSD and depression symptoms over six months.
Parental Separation Linked to Increased Mental Disorder Risk in University Students
A large Norwegian survey of 52,968 students finds higher rates of depression, anxiety, and PTSD years after family dissolution.
Low Diaphragm Thickening Fraction at One Hour Predicts Noninvasive Ventilation Failure
Bedside ultrasound of the diaphragm after 60 minutes of support identifies patients likely to require endotracheal intubation.
Tranexamic Acid Reduces Major Bleeding in Urologic Surgery
A randomized trial of 1,124 patients shows TXA reduces major bleeding by 3.4% without significantly increasing 30-day thrombotic risk.
IL-15 Receptor Deficiency Drives Depressive Behaviors via Microglial Synapse Pruning in Mice
Loss of IL-15RA signaling triggers prefrontal cortex synapse loss through the CX3CL1 pathway, offering a potential target for depression.
Acetate Supplementation May Reduce Psychotropic-Induced Weight Gain and Dyslipidemia
A case-series shows delayed-release acetate capsules improve metabolic markers and shift gut microbiota toward butyrate-producing bacteria.