Steep Tibial Slope Increases ACL Graft Failure Despite Lateral Augmentation
A 6-year cohort study finds that posterior tibial slope exceeding 12 degrees significantly raises rerupture risk even with tenodesis.
Behavioral Nursing Model Improves Glycemic Control and Cognition in Older Diabetes Patients
A three-month Information-Motivation-Behavioral Skills intervention reduced HbA1c and psychological distress while improving cognitive scores.
Transcriptional Map Identifies 37 Interneuron Subtypes in Human Prefrontal Cortex
Researchers used single-nucleus RNA sequencing to define molecular signatures of somatostatin and parvalbumin cells in healthy adults.
Cell-Specific Genetic Mapping Links Neuronal and Immune Pathways to Neuropsychiatric Risk
Analysis of six major disorders identifies 345 risk genes, highlighting the role of microglia and astrocytes in disease pathogenesis.
Emergency Laparotomy Survivors Face High Readmission and Inconsistent Follow-up
A multicenter study of 557 patients reveals that nearly 20% return to the hospital within 30 days of discharge.
Complex Endovascular Aortic Repair Shows 83 Percent Five Year Survival
A 14-year study of 916 patients reveals high technical success but a 60 percent reintervention rate following complex endovascular repair.
Estradiol Patches Noninferior to LHRH Agonists in Prostate Cancer
A phase 3 trial shows transdermal estradiol maintains metastasis-free survival while reducing hot flashes in locally advanced disease.
Noninvasive Fascial Traction Increases Primary Closure Rates in Open Abdomens
Adding a traction device to negative pressure therapy reduces the 12-month incisional hernia risk from 63.1% to 14.1%.
Participation-Focused Training Improves Immediate Post-Stroke Executive Function in Randomized Trial
Strategy training shows short-term cognitive gains in stroke survivors, though benefits do not persist at three-month follow-up.
Immune-Guided Strategy Reduces CMV Disease in Kidney Transplant Recipients
Early assessment of cell-mediated immunity allows for targeted prophylaxis, lowering symptomatic disease rates in seropositive patients.
Systemic Inflammation Triggers Sex-Specific Social Proximity Changes in Mice
While both sexes show similar sickness behaviors, acute immune activation specifically reduces social distance in male mice.
Co-Occurring Suicidal Ideations Triple Risk of Adolescent Behavior
A longitudinal study finds that adolescents with both active and passive ideation face a 3.13-fold increase in 3-month behavioral risk.