Paramedic Patella Reduction Reduces Hospital Transport and Dislocation Time
A retrospective analysis of 1,210 patients shows a 91.8% success rate for prehospital reduction, cutting dislocation time by 71 minutes.
Inconsistent ALS Trial Analysis Increases Risk of False Positive Results
A review of 45 clinical trials shows that statistical method choice can swing treatment effect estimates by over three standard deviations.
PIEZO1 Variant Reclassification Identifies Three Clinical Phenotypes in DHS1
A new framework reclassifies 1,000 variants of uncertain significance and links specific protein domains to iron overload risk.
Short-Interval Botulinum Toxin Injections Induce Sustained Glabellar Muscle Suppression
A three-year electromyographic study shows that frequent onabotulinumtoxinA dosing maintains muscle paralysis 48 weeks after treatment ends.
Employment and Family Dynamics Mitigate Maternal Anxiety in Multi-Child Households
A study of 4,215 mothers indicates that employment status and family conflict are stronger predictors of mental health than parity alone.
Immersive Virtual Reality Improves Naming in Chronic Non-Fluent Aphasia
A randomized trial shows immersive therapy yields higher gains in oral motor function and patient enjoyment than conventional methods.
Metabolic Disease Burden Rises in Southern Italy Despite National Declines
A 33-year analysis reveals widening geographic disparities in metabolic health and a growing proportion of unattributable disease burden.
Age, Rhythm, and Low-Flow Duration Predict Neurological Recovery After ECPR
A 14-year cohort study identifies specific predictors to help clinicians select cardiac arrest patients for extracorporeal resuscitation.
GABAA Gain-of-Function Mutation Triggers Seizures via Interneuron Network Collapse in Mice
A study of the GABRB3 p.(Glu77Lys) variant reveals how enhanced inhibitory signaling paradoxically drives cortical hyperexcitability.
Three or More Breast Cancer Foci Increase Specific Mortality Risk
A Swedish cohort study of 71,607 women finds that multifocality independently predicts worse survival despite traditional staging.
Memantine Reduces Premature Atrial Contractions and New-Onset Atrial Fibrillation
A phase 2 trial shows targeting cardiac N-methyl-D-aspartate receptors significantly lowers atrial ectopy and tachyarrhythmia burden.
School Transition Drives Adolescent Well-being Decline More Than Aging
A longitudinal study of 20,910 students shows secondary school transition triggers well-being deficits lasting over two years.