Biceps Tenotomy and Tenodesis Show Moderately Robust Clinical Equivalence
A meta-analysis using the reverse continuous fragility index suggests current evidence for similar outcomes is statistically stable.
Anesthesia Trials Lack Precise Definitions for Perioperative Disruptions
A review of 139 trials finds 60% fail to report how they handle events like surgery cancellations or treatment switching.
French Cohort Study Maps Perinatal Risks for Neurodevelopmental Disorders
A study of 7.4 million children identifies shared and distinct risk factors for ADHD, autism, and intellectual disability.
Endothelial Expansion Drives Vascular Hyalinization in Castleman Disease
Transcriptomic analysis identifies endothelial-B cell crosstalk as a primary driver of stromal dysregulation and systemic inflammation.
Open-Source AI Models Accurately Classify Pediatric Pneumonia on Radiographs
Large language models match physician adjudication of free-text reports, surpassing traditional machine learning in the emergency department.
Cystatin C Discrepancy Predicts Kidney Injury and Death in Cell Therapy
A 30% gap between creatinine and cystatin C filtration estimates identifies high-risk transplant and T-cell therapy candidates.
Adding Tobramycin to Vancomycin Powder Does Not Reduce Tibial Fracture Infections
A randomized trial of 1528 patients shows dual intrawound antibiotic powder offers no benefit over vancomycin alone in high-risk fractures.
Ketamine Increases Brain PDE4 Binding in Rats and Monkeys
Subanesthetic doses rapidly boost cAMP signaling, suggesting a molecular pathway for the drug's fast-acting antidepressant effects.
AI Risk Scores Link to Low-Grade Malignancy Before Clinical Detection
Retrospective analysis shows AI-generated risk scores from prior-year mammograms correlate with tumor grade and invasive lobular pathology.
Preoperative Beta Connectivity Predicts Delirium Risk in Older Surgical Patients
A multicenter study finds reduced brain network communication at baseline identifies vulnerability, though EEG patterns recover by 3 months.
Thalamocortical Connectivity and Immune Dysregulation Linked to Suicidal Ideation in Depression
Researchers identify a caudal temporal thalamus network and peripheral gene expression patterns that distinguish suicidal risk in patients.
Eccentric Cycling Matches Concentric Training for Post-COVID-19 Walking Recovery
An 8-week trial shows eccentric cycling is safe and improves walking distance, though it offers no advantage over concentric exercise.