C4A Complement Pathway Decouples from C1Q in First-Episode Psychosis
A study of 113 patients shows that C4A levels shift independently of C4B in the cerebrospinal fluid during early-stage psychosis.
Exogenous Hormones Associate With Reduced Dementia Risk in UK Biobank Cohort
Use of oral contraceptives and hormone replacement therapy correlates with lower rates of Alzheimer's disease and vascular dementia.
Clinical Criteria for LATE Distinguish Cognitive Trajectories from Alzheimer Disease
A study of 3,606 patients shows isolated LATE progresses slower than Alzheimer disease, while comorbid pathology accelerates decline.
Corticostriatal Connectivity Shifts as Putaminal Dopamine Depletion Reaches 50 Percent
A study of 326 patients identifies a critical threshold where compensatory motor circuits fail and clinical symptoms accelerate.
Distinct Cortical Thickness Patterns Define Positive and Negative Schizotypy
MRI analysis of 2730 healthy adults links subclinical traits to specific neurotransmitter systems and neurodevelopmental disorders.
Ceruloplasmin Deficiency Linked to Fusiform Gyrus Pathology in Autism Subtype
Low ceruloplasmin levels drive lipid and myelin imbalances in children with autism and atypical visual processing.
Apixaban Reduces Recurrent Stroke in Patients Without High-Risk Hypertension
An ARCADIA trial analysis shows apixaban is more effective than aspirin only when severe hypertension and cardiac hypertrophy are absent.
Hodgkin Lymphoma Survivors Face Quality of Life Deficits Decades After Diagnosis
A nationwide study shows persistent fatigue and dyspnea in survivors compared to the general population, even 10 years post-treatment.
EEG Topological Mapping Distinguishes Mild from Moderate Stroke with 86% Accuracy
Persistent homology identifies higher-order network disruptions in the prefrontal cortex to improve objective stroke severity assessment.
Cibisatamab and FAP-4-1BBL Show Activity in Refractory Colorectal Cancer
A phase 1b trial finds that combining a CEA-targeted bispecific antibody with localized 4-1BB co-stimulation induces objective responses.
Cannabis Use Blunts Neurocognitive Development in Adolescents
Longitudinal data and hair toxicology link THC exposure to flattened growth in memory and processing speed from ages 9 to 17.
One in Four Non-Comatose Cardiac Arrest Survivors Face Poor Outcomes
A registry analysis identifies age, motor response, and pH levels as key predictors of 30-day recovery in patients who avoid post-arrest coma.