Cartilage Damage Increases Between Primary and Revision ACL Reconstruction
Registry data show a 0.7% increase in the odds of chondral lesions for every month of delay between initial injury and revision surgery.
High-Intensity tACS Improves Chronic Insomnia by Modulating Brain Networks
A randomized trial shows 15 mA stimulation reduces sleep index scores and reorganizes functional connectivity in hyperarousal circuits.
Gut Microbiome Signature Identifies Premanifest Parkinson’s Disease Risk
Metagenomic analysis reveals a microbial state in GBA1 carriers that correlates with prodromal symptoms and disease progression.
Childhood Maltreatment Mediates Neural Influence on Depressive Temperament
Hippocampal and insular activity correlate with depressive traits through the subjective appraisal of early life trauma.
Radiographic Bone Texture Analysis Identifies Risk of Femoral Stem Subsidence
Lower texture energy and mean intensity on preoperative radiographs correlate with early implant migration exceeding two millimeters.
Autism Shares Genetic Risk Loci With Diabetes and Heart Disease
Large-scale genomic analysis identifies 100 shared loci linking autism spectrum disorder to metabolic and cardiovascular phenotypes.
Intestinal Permeability Triggers Atrial Fibrillation via JNK2 Activation in Mice
Researchers identified a signaling axis where leaky gut-associated cytokines activate cardiac JNK2 to cause calcium-handling abnormalities.
Infrequent Healthcare Contact and Previous Attempts Linked to Intoxication at Suicide
A Finnish registry study of 6,892 deaths identifies clinical profiles and diagnostic factors associated with acute alcohol use.
Daily Task Frequency Correlates With Objective Activity in Cardiac Patients
A study of 1,126 patients shows that housework and leisure activities drive higher step counts and moderate-to-vigorous exertion.
Lifestyle Intervention Benefits Cognition in Older Adults With Low Hippocampal Volume
A randomized trial shows intensive lifestyle coaching preserves cognition in high-risk patients despite unchanged brain biomarker trajectories.
Open-Source Models Accurately Identify Pediatric Pneumonia in Radiology Reports
Large language models achieve F1 scores up to 0.97, surpassing traditional machine learning in classifying free-text chest X-ray reports.
High-Dose Calcium Chloride Reduces 24-Hour Mortality in Trauma Patients
A 1:2 ratio of calcium chloride to whole blood units lowered the odds of early death by 84% in a retrospective cohort study.