White Matter Coupling Imbalance Marks Early HIV Neurocognitive Impairment
Structural demyelination and functional reorganization in white matter tracts correlate with clinical status in asymptomatic HIV patients.
Mediterranean Diet Preserves White Matter Integrity in Hispanic and Latino Adults
Higher adherence correlates with lower white matter hyperintensity volume and better global cognition through cardiovascular health pathways.
Venlafaxine Linked to Probable Induction of De Novo Vocal Tics
A case report identifies the first instance of vocal tics following SNRI use, likely due to fronto-striatal dopamine dysregulation.
Severe Childhood Malaria Impairs Cognition Up to 15 Years Later
Ugandan children who survive cerebral malaria or severe malarial anemia show persistent cognitive and math deficits up to 15 years later.
Thrombectomy Increases Tissue Salvage in Distal Vessel Occlusion Stroke
A post hoc analysis of the DISTAL trial shows endovascular therapy preserves more at-risk brain tissue than medical management alone.
Neuropsychiatric Symptoms and CSF Markers Predict General Paresis Outcomes
A 12-month study identifies depression, apathy, and baseline inflammatory markers as key indicators of prognosis in neurosyphilis.
Blood-Brain Barrier Integrity Dictates Serum GFAP Accuracy in Cognitive Impairment
A study of 74 patients shows that serum biomarkers only strongly correlate with central pathology when the blood-brain barrier is disrupted.
Exogenous Hormones Associate With Reduced Dementia Risk in UK Biobank Cohort
Use of oral contraceptives and hormone replacement therapy correlates with lower rates of Alzheimer's disease and vascular dementia.
Clinical Criteria for LATE Distinguish Cognitive Trajectories from Alzheimer Disease
A study of 3,606 patients shows isolated LATE progresses slower than Alzheimer disease, while comorbid pathology accelerates decline.
Corticostriatal Connectivity Shifts as Putaminal Dopamine Depletion Reaches 50 Percent
A study of 326 patients identifies a critical threshold where compensatory motor circuits fail and clinical symptoms accelerate.
Apixaban Reduces Recurrent Stroke in Patients Without High-Risk Hypertension
An ARCADIA trial analysis shows apixaban is more effective than aspirin only when severe hypertension and cardiac hypertrophy are absent.
EEG Topological Mapping Distinguishes Mild from Moderate Stroke with 86% Accuracy
Persistent homology identifies higher-order network disruptions in the prefrontal cortex to improve objective stroke severity assessment.