Lower Tau PET Sensitivity in Older Men Reflects Reduced Tangle Density
Flortaucipir PET sensitivity for advanced Alzheimer pathology drops to 42% in patients over 83, mirroring lower biological tangle burdens.
Sex Not Independently Linked to Post-Arrest Neurological Recovery
Observed survival disparities between men and women disappear after adjusting for initial rhythm and arrest etiology.
7 Tesla MRI Reveals Rapid Neural Connectivity Shifts During Cognitive Tasks
Healthy adults transition from surveillance to automated processing within minutes of mental exertion despite stable behavioral performance.
AI Model Predicts Glioblastoma Infiltration Beyond Visible Tumor Margins
A prospective trial validates an AI tool using biopsies to map microscopic tumor spread and predict survival in glioblastoma patients.
Bitemporal ECT and rTMS Plus SSRIs Reduce Suicidal Ideation
A network meta-analysis of 58 trials finds nonconvulsive brain stimulation alone is ineffective for suicidal ideation without medication.
Advanced MRI Detects Occult Neuronal Loss in Asymptomatic MCA Occlusion
Soma and neurite density imaging reveals microstructural gray matter damage in stroke-free patients with chronic arterial occlusion.
Cerebral Oximetry Fails to Improve 2-Year Outcomes in Preterm Infants
A phase 3 trial of 1,601 infants shows no reduction in death or disability when using oximetry to guide early postnatal care.
Ubiquinol Slows Motor Decline in Multiple System Atrophy Trial
A Phase 2 trial provides the first placebo-controlled evidence of disease modification by targeting mitochondrial dysfunction in MSA.
Iron Deficiency Drives Dopaminergic Hypersensitivity in Rodent Restless Legs Model
A study in mice links brain iron deficiency to increased GABA release in the striatal-entopeduncular pathway, mimicking opioid withdrawal.
Routine Dementia Screening Shows No Benefit or Harm for Family Members
A randomized trial finds cognitive screening in primary care does not impact family quality of life, preparedness, or psychological distress.
Valproate Linked to Higher Mortality in Patients With Dementia and Epilepsy
A Swedish registry study finds lamotrigine and levetiracetam associated with better survival than valproate or carbamazepine.
Alteplase Before Thrombectomy Loses Value After 170 Minutes
A 16-country analysis shows bridging therapy for large vessel occlusion is only cost-effective when initiated early after stroke onset.