Plasma p-tau217 Assays Show High Specificity for Alzheimer’s Diagnosis
Three diverse assay technologies demonstrate 100% specificity in differentiating Alzheimer’s from vascular and frontotemporal dementias.
GNAO1-Related Disorders Follow Non-Degenerative Course Despite Progressive Movement Symptoms
A longitudinal study of 66 patients shows cognitive stability while severe cases face functional burden from worsening movement disorders.
Early EEG Findings Guide Shorter Sedation After Cardiac Arrest
Patients with favorable EEG patterns within 12 hours of arrest saw mechanical ventilation and ICU stays reduced by over 50 percent.
Asundexian Reduces Recurrent Stroke Without Increasing Major Bleeding
Adding the Factor XIa inhibitor asundexian to standard antiplatelet therapy safely lowers recurrent stroke risk in high-risk patients.
Glial GLRX3 Enzyme Drives Chronic Oxaliplatin-Induced Pain in Aged Models
A redox circuit in the dorsal root ganglion identifies potential biomarkers and therapeutic targets for age-related chemotherapy toxicity.
Neural Rhythms in Language and Default-Mode Networks Predict Reading Recall
Combined EEG and MRI data reveal that specific frequency patterns in brain networks correlate with a patient's ability to remember text.
High-Intensity tACS Improves Chronic Insomnia by Modulating Brain Networks
A randomized trial shows 15 mA stimulation reduces sleep index scores and reorganizes functional connectivity in hyperarousal circuits.
Gut Microbiome Signature Identifies Premanifest Parkinson’s Disease Risk
Metagenomic analysis reveals a microbial state in GBA1 carriers that correlates with prodromal symptoms and disease progression.
Lifestyle Intervention Benefits Cognition in Older Adults With Low Hippocampal Volume
A randomized trial shows intensive lifestyle coaching preserves cognition in high-risk patients despite unchanged brain biomarker trajectories.
Spinal Cord Area Loss Predicts Myelopathy in Severe Cervical Ossification
Percentage reduction in cord cross-sectional area shows higher diagnostic accuracy than traditional bony canal measurements.
Beta-1 Blockers May Reduce Vascular Dementia Risk in Genetic Analysis
A Mendelian randomization study suggests beta-1 adrenergic antagonism protects white matter, while ACE inhibition may increase risk.
Planetary Health Diet Linked to Lower Risk of Stroke and Depression
A UK Biobank study of 69,370 adults finds high adherence to sustainable eating reduces brain disorder risk via slower biological aging.