New England Journal of Medicine
35 articles tagged "New England Journal of Medicine"
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Microaxial Flow Pump Fails to Improve Outcomes in High-Risk PCI
A randomized trial of 300 patients shows elective left ventricular unloading does not reduce major adverse events at 12 months.
APT-Sepsis Program Lowers Maternal Infection Mortality and Morbidity
A cluster-randomized trial of 431,394 women shows a 32% reduction in severe infection-related outcomes using a standardized care bundle.
MiniDock MTB Swab Test Meets WHO Accuracy Targets for Tuberculosis
A prospective study of 1380 patients shows tongue and sputum swabs provide accurate molecular detection of pulmonary tuberculosis.
Mim8 Prophylaxis Reduces Bleeding in Hemophilia A with or without Inhibitors
Phase 3 data show weekly or monthly subcutaneous Mim8 significantly lowers bleeding rates compared to on-demand and prior factor therapy.
Pulsed Field Ablation Reduces Recurrence in Persistent Atrial Fibrillation
First-line pulsed field ablation showed a 56% success rate at 12 months compared to 30% for antiarrhythmic drugs in a randomized trial.
Balanced Fluids and Saline Show Similar Outcomes in Pediatric Septic Shock
A large trial of over 8,000 children found no difference in kidney events or mortality between balanced crystalloids and 0.9% saline.
Triple-Pill Therapy Reduces Recurrent Stroke Risk After Intracerebral Hemorrhage
A low-dose combination of telmisartan, amlodipine, and indapamide lowered systolic blood pressure and major cardiovascular events.
Ketamine Does Not Reduce 28-Day Mortality Compared With Etomidate
A randomized trial of 2,365 critically ill adults found no survival benefit for ketamine, despite a higher rate of cardiovascular collapse.
Nirmatrelvir-Ritonavir Fails to Reduce Hospitalization in Vaccinated Outpatients
Two randomized trials show no significant clinical benefit for high-risk adults with prior immunity from vaccination or infection.
Estradiol Patches Noninferior to LHRH Agonists in Prostate Cancer
A phase 3 trial shows transdermal estradiol maintains metastasis-free survival while reducing hot flashes in locally advanced disease.
Endovascular Therapy Eases Post-Thrombotic Syndrome but Increases Bleeding
Iliac-vein stenting with enhanced antithrombotics improves symptoms and quality of life at six months, despite a higher bleeding risk.
Routine Prednisolone Does Not Prevent Coronary Lesions in Kawasaki Disease
A large randomized trial shows that adding steroids to standard therapy does not protect the coronary arteries of unselected children.