Obesity and Prediabetes Rates Rise Among Northern Great Plains Children
A multi-year screening of American Indian students shows obesity rates exceeding 40% and a doubling of prediabetes prevalence.
GNAO1-Related Disorders Follow Non-Degenerative Course Despite Progressive Movement Symptoms
A longitudinal study of 66 patients shows cognitive stability while severe cases face functional burden from worsening movement disorders.
Chronotherapeutic Protocol Advances Circadian Timing and Extends Adolescent Sleep
A two-week intervention using light-modulating glasses and scheduling increased weeknight sleep by 47 minutes in high school students.
Open-Source Models Accurately Identify Pediatric Pneumonia in Radiology Reports
Large language models achieve F1 scores up to 0.97, surpassing traditional machine learning in classifying free-text chest X-ray reports.
Resilience Alters Symptom Networks Linking Bullying to Depression in Adolescents
Network analysis reveals that low resilience strengthens the ties between social exclusion and depressive symptoms like anhedonia.
Early DHEA Levels Predict Depression in Adolescent Males but Not Females
A longitudinal study finds that while DHEA at age nine increases risk for males, adrenal hormones do not explain higher female prevalence.
Students With Moderate Distress Show High Rate of Worsening
A 10-month analysis finds this group is a key target for intervention, with problematic internet use predicting negative outcomes.
Lactate Enzyme Overexpression Enhances Remyelination in Animal Models
Restoring glycolysis and lactate production in oligodendrocyte precursors overcomes epigenetic silencing to stimulate myelin repair.
Serum Neurofilament Light Chain Identifies Subclinical Axonal Injury in SMA Neonates
Elevated serum neurofilament light chain levels predict two-year motor outcomes and reveal active denervation before clinical symptoms appear.
US Adult Obesity Projected to Reach 47 Percent by 2035
An analysis of over 11 million adults reveals severe racial and geographic disparities as obesity rates continue to climb nationwide.
Vitamin C Reverses Depression-Like Behavior in Female Mice via D2 Receptors
A single dose of ascorbic acid restored dopamine D2 receptor signaling in the prefrontal cortex, rapidly alleviating depression in mice.
Young Children Require Higher Benzodiazepine Doses for PICU Ventilation
A retrospective cohort study reveals that children under five receive significantly higher weight-adjusted doses of midazolam and lorazepam.