The Briefing · Emergency & Critical Care
Continuous newsroom coverage of evidence in Emergency & Critical Care — newest first.
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24 stories-
Lamotrigine-Topiramate Duotherapy Increases Congenital Malformation Risk Fourfold
A large registry study identifies a significant risk increase for specific antiseizure drug combinations used during the first trimester.
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Most Chronic Cough Patients Do Not Achieve Patient-Defined Control Post-Treatment
A single-center observational study established patient-anchored criteria for cough control, finding only 26% of patients met them.
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Fibrin Binding Explains Reduced Circulating Myosin After Trauma
Direct binding of skeletal muscle myosin to fibrin clots may clarify its role in trauma-induced coagulopathy and observed plasma level changes.
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Digital Decision Aid Boosts STI Testing in ED for Young Adults
A randomized trial shows a smartphone-based tool significantly increases gonorrhea/chlamydia and pharyngeal STI testing rates in emergency department
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Ibrutinib Response in WM Linked to Clonal Evolution, T-Cell Dynamics
A single-cell analysis reveals distinct tumor evolution patterns and immune cell changes predicting ibrutinib outcomes in Waldenström macroglobulinemi
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Cluster Headache Prevalence Rises as Female Incidence Surpasses Males in Norway
A 14-year registry study shows the historical male predominance in cluster headache is vanishing as female incidence rates climb.
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Anti-C5a Antibody STSA-1002 Shows Favorable Safety, Reduced Mortality in ARDS
A phase 1b/2 trial indicates STSA-1002 is well tolerated and associated with lower 28-day mortality in viral pneumonia-induced ARDS.
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Younger Age, Autoimmune Disease Linked to Recurrent, Bilateral Facial Palsy
A retrospective study identifies specific risk factors for recurrent and bilateral facial palsy in Bell's Palsy and Ramsay Hunt Syndrome patients.
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ACEP launches 2025 clinical policy for Endotracheal Intubation in the Emergency Department
The new guideline prioritizes physiologic optimization, recommending noninvasive ventilation for preoxygenation and specific induction agents.
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EUSEM launches 2025 guideline for Acute Pain Management in Emergency Situations
This updated guideline fundamentally shifts acute pain management in emergency settings towards multimodal, non-opioid first-line therapies.
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ERC and ESICM launch 2025 guideline for Post-Resuscitation Care
New guidelines emphasize comprehensive diagnostic imaging, refined temperature control, and a multimodal approach to neurological prognostication.
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AHA and ASA launch 2026 guideline for Acute Ischemic Stroke management
The new guideline introduces tenecteplase as an alternative to alteplase for IV thrombolysis and expands recommendations for pediatric stroke care.
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SCCM and ESICM launch 2026 guideline for Sepsis and Septic Shock Management
The updated Surviving Sepsis Campaign guidelines emphasize earlier, more precise interventions, including new screening tool recommendations.
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AHA and ACC launch 2026 guideline for Acute Pulmonary Embolism in Adults
A new clinical categorization system for acute PE refines risk stratification, enabling more precise management and expanding outpatient treatment.
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Military Blood Supply Insufficient for Large-Scale Combat Operations
Simulation reveals current Forward Resuscitative Surgical Detachment blood strategies, even with walking blood banks, fail rapidly under high casualty
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Favipiravir Safe, Well-Tolerated for Mild-to-Moderate Lassa Fever
A phase 2 trial in Nigeria provides pharmacokinetic data and supports favipiravir as an alternative to ribavirin for Lassa fever.
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Cameroon Football Reveals Gaps in Cardiac Screening, Emergency Preparedness
A cross-sectional study highlights critical deficiencies in cardiovascular screening and sudden cardiac arrest response among football teams in Camero
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ED Nudge Strategy Increases Naltrexone Prescribing for Alcohol Misuse
A multicomponent emergency department protocol significantly raised naltrexone initiation for patients with alcohol-related diagnoses.
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Demographics Influence Etiology in 2,052 Patients With Late-Onset Seizures
A multicenter study finds that while stroke remains common, neurodegeneration and unexplained causes dominate the geriatric epilepsy profile.
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Intravenous Magnesium Sulfate Reduces Rescue Analgesia for Acute Headache
A randomized trial finds adjunctive magnesium sulfate increases treatment success and patient satisfaction, despite pain reduction not meeting clinica
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Thrombectomy Improves Functional Independence in Medium-Vessel Occlusion Stroke
A randomized trial shows endovascular thrombectomy increases functional independence but also raises symptomatic intracranial hemorrhage risk in mediu
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SSPOP Mutations Linked to Pediatric Epilepsy and Developmental Disorders
Researchers identify pathogenic variants in a supposed pseudogene, expanding the diagnostic landscape for unexplained neurodevelopmental delay.
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NPM1-Mutated AML: Nuclear Condensates Drive HOX/MEIS1 Expression, Inform Menin Inhibitor Action
New research clarifies how mutant NPM1 forms nuclear condensates, sustaining oncogenic transcription and explaining menin inhibitor efficacy.
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Specific Patient Profiles Face Up to 30% Risk of Severe Asthma Progression
A large Danish cohort study identifies key risk factors and patient characteristics associated with progression from mild-to-moderate to severe asthma