The Briefing · Emergency & Critical Care
Continuous newsroom coverage of evidence in Emergency & Critical Care — newest first.
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Bupivacaine-Dexamethasone TAP Blocks Reduce LOS, Opioid Use in DIEP Flap Patients
A retrospective study suggests bupivacaine with dexamethasone improves early pain control and shortens hospital stay after DIEP flap breast reconstruc
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ICU Caregiver Financial Strain Linked to Psychological Distress, Medical Mistrust
A study of 97 ICU caregivers found that over 60% reported difficulty paying for care, correlating with increased anxiety, depression, PTSD, and decisi
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Ensitrelvir Reduces COVID-19 Incidence by 6.1% in Household Contacts
An oral SARS-CoV-2 3C-like protease inhibitor significantly lowers infection rates when given as postexposure prophylaxis.
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Daratumumab-VCd Improves Survival, Organ Function in AL Amyloidosis
Final ANDROMEDA analysis confirms sustained benefits of D-VCd for newly diagnosed light-chain amyloidosis, including overall survival.
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Critically Ill Women in India Receive Less Organ Support, Show Similar Mortality
A large registry-embedded cohort study reveals sex-based differences in critical care provision without impacting adjusted mortality.
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Indian ICUs: Women Receive Less Organ Support, Similar Mortality to Men
A large registry-embedded cohort study in India reveals sex-based differences in critical care resource utilization.
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Gram-Negative Bacteria Dominate Neonatal Infection Deaths in LMICs
A multicountry study identifies Klebsiella pneumoniae and Acinetobacter baumannii as leading causes of neonatal infection mortality.
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Extra-Pulmonary TB Linked to Persistent Lung Function Deficits
A new study reveals that extra-pulmonary tuberculosis survivors experience lasting respiratory impairment, similar to pulmonary TB.
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Extrapulmonary TB Linked to Persistent Lung Function Deficits, Respiratory Symptoms
A new study reveals that individuals treated for extrapulmonary tuberculosis frequently develop lasting ventilatory defects and respiratory symptoms.
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Sutureless Robotic Partial Nephrectomy Noninferior to Renorrhaphy for Renal Tumors
A randomized controlled trial indicates sutureless off-clamp robotic partial nephrectomy offers comparable surgical quality for cT1-2N0M0 renal tumors
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ECPR for OHCA in Singapore: Cost-Effective, but Sensitive to Transport Delays
A simulation-based analysis suggests ECPR for refractory OHCA in Singapore is cost-effective, though transport time significantly impacts its economic
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Telitacicept Reduces Proteinuria in IgA Nephropathy: Phase 3 Interim Analysis
A dual BAFF and APRIL antagonist significantly lowers urinary protein-to-creatinine ratio in adults with IgA nephropathy at high risk of progression.
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CPES Score May Better Identify PE Patients Needing Advanced Intervention
A retrospective study suggests the Composite Pulmonary Embolism Shock score offers improved prediction for advanced interventions in PE.
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CPES Score Identifies PE Patients Needing Advanced Intervention
A retrospective study finds the Composite Pulmonary Embolism Shock score particularly effective in predicting the need for advanced therapies.
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UK and Ireland Neonatal Stroke Incidence: 9.0 per 100,000 Live Births
A new surveillance study details the epidemiology, clinical patterns, and short-term outcomes of neonatal stroke in the UK and Ireland.
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UK Neonatal Stroke Incidence: 9.0 per 100,000 Live Births, Varied Presentations
A new surveillance study details the incidence, clinical features, and initial management of neonatal stroke in the UK and Ireland.
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Dual PH Therapy Before BPA Reduces Complications, Improves Outcomes in CTEPH
A Dutch registry study indicates that dual pulmonary hypertension-targeted medical therapy improves safety and efficacy of balloon pulmonary angioplas
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Dual PH-Targeted Therapy Reduces BPA Complications, Improves Outcomes in CTEPH
A Dutch registry study indicates that dual pulmonary hypertension-targeted medical pretreatment lowers periprocedural risks and enhances clinical bene
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Acute Kidney Injury Predicts Increased Risk of Stroke and Dementia
A meta-analysis of 11 million patients links acute renal insults to a 35% higher stroke risk and nearly fivefold 90-day poststroke mortality.
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CMR and NT-proBNP Improve Risk Prediction in Hypertrophic Cardiomyopathy
A prospective registry study identifies myocardial scar and natriuretic peptide levels as key predictors of long-term adverse outcomes.
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Patient-Level Adherence Drives Enhanced Recovery Benefits in Pediatric GI Surgery
A stepped-wedge trial shows that while site-level ERP implementation may not reduce length of stay, patient-level adherence does.
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High Antiplatelet Resistance, Elevated von Willebrand Factor in Vascular Surgery Patients
A new study reveals a high prevalence of antiplatelet resistance, particularly to clopidogrel, and elevated von Willebrand factor in patients undergoi
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Lower Oxygen Saturation Target Reduces Pediatric Hospital Stay, Oxygen Therapy
A multicenter trial suggests targeting 88% peripheral oxygen saturation in children with acute respiratory illness shortens hospitalizations.
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JMJD1C Deficiency Drives Pathogenic Antibody Production in Heparin-Induced Thrombocytopenia
Loss of the histone demethylase JMJD1C triggers B-cell hyperactivation and the production of platelet-activating antibodies.