The Briefing · Emergency & Critical Care
Continuous newsroom coverage of evidence in Emergency & Critical Care — newest first.
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Extracorporeal Limb Perfusion Does Not Exacerbate Bleeding in Porcine Trauma Model
A study of Lower Extremity Extracorporeal Distal Revascularization shows stable clot integrity despite uncontrolled vascular injuries.
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Tirzepatide Reduces Major Kidney Events More Than Dulaglutide
In patients with type 2 diabetes and cardiovascular disease, tirzepatide lowered the risk of renal outcomes by 23% over four years.
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Commercial AI for Lung Cancer Screening Lacks Full Guideline Alignment
An analysis of 16 CE-marked products reveals gaps in managing cystic lesions and a lack of prospective evidence for patient outcomes.
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Cerebrotendinous Xanthomatosis Drives Recurrent Stroke After PFO Closure
A 23-year-old's recurrent M1 occlusion reveals how metabolic drivers of premature atherosclerosis can mimic or coexist with structural defects.
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Intra-Arterial Alteplase Improves Recovery After Successful Thrombectomy
Adjunctive thrombolysis increased 90-day functional independence by 15% but was associated with a nearly 6% increase in mortality.
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Children Witness Nearly Ten Percent of US Violent Deaths and Suicides
A CDC surveillance analysis reveals that most child-witnessed fatal events occur in homes and involve firearms or domestic conflict.
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Medicaid Expansion Linked to Lower Mortality in Young Adult Dialysis Patients
A cohort study shows a 1.8 percentage point drop in one-year mortality for young adults starting dialysis after Medicaid expansion.
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Redlining and Modern Loan Denials Drive Chicago Firearm Homicides
Historical housing maps and current economic discrimination act as independent, measurable factors in urban firearm violence disparities.
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Dihydroartemisinin-Piperaquine Reduces Early Plasmodium vivax Recurrence Compared With Chloroquine
A randomized trial in Brazil shows dihydroartemisinin-piperaquine effectively prevents early malaria recurrence when primaquine is delayed.
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Early Cystography After Bladder Repair Reduces Catheter Time and Infections
Imaging within seven days of traumatic bladder repair safely shortens catheterization and lowers infection rates without missing leaks.
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Single Sigmoidoscopy Reduces Male Colorectal Cancer Death at 23 Years
A Norwegian trial shows a single screening sigmoidoscopy provides long-term protection for men, but mortality benefits are absent in women.
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Tenecteplase Before Thrombectomy Does Not Improve Late-Window Stroke Outcomes
A phase 3 trial in patients with proximal MCA occlusions found no functional benefit to adding tenecteplase between 4.5 and 24 hours.
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Digoxin Reduces Heart Failure Risk in Rheumatic Heart Disease
A randomized trial in India shows low-dose digoxin decreases the composite risk of death or worsening heart failure by 18 percent.
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Nurse-Led School CPR Program Multiplies Community Training Reach
Students using low-cost manikins trained an average of 2.4 family members, significantly expanding the pool of potential bystanders.
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Transradial Access Does Not Increase Radiation in Aneurysm Treatment
A comparative study finds no significant difference in radiation dose between radial and femoral routes for endovascular repair.
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Small Vessel Disease Explains Reduced Thrombectomy Benefit in Older Patients
A secondary analysis of the RESILIENT trial finds that CT markers of brain frailty, not age alone, predict poor functional outcomes.
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Low-Dose Digoxin Fails to Reduce Heart Failure Events in Randomized Trial
A study of 1,001 patients found targeting low serum concentrations did not significantly lower mortality or urgent hospital visits.
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Early Magnesium Sulfate Linked to Lower Mortality in Pneumonia
A retrospective analysis of 9,203 ICU patients suggests early intravenous magnesium may reduce 30-day mortality risk by 16 percent.
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Resident Response Vehicles Increase Exposure to High-Acuity Prehospital Care
A five-year study shows dedicated field vehicles provide residents with over 1,300 cardiac arrests and 2,000 medical control consults.
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Quality Improvement Shortens Time to Antibiotics in Pediatric Intestinal Failure
Multidisciplinary interventions reduced median cephalosporin delivery time by 58% for children with suspected central line infections.
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Glofitamab Shows High Response Rates in Refractory Aggressive B-Cell Lymphoma
Real-world data link baseline CD4+ effector T cells and early CD8+ expansion to improved outcomes with bispecific antibody therapy.
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Auditory Slow-Wave Stimulation Reduces Axonal Damage in Rat Brain Injury Model
Closed-loop acoustic triggers during deep sleep preserved white matter integrity and cognitive function in a preclinical study of TBI.
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Biliopancreatic Diversion Shows Durable Weight Loss but High Long-Term Morbidity
A 50-year cohort study finds universal diabetes remission and sustained weight loss alongside an 86% nutritional complication rate.
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Paramedic Discharge Protocols Reduce Call Times but Remain Underutilized
Prehospital discharge for resolved seizures and hypoglycemia cuts call duration by half compared to emergency department transport.