The Briefing · Emergency & Critical Care
Continuous newsroom coverage of evidence in Emergency & Critical Care — newest first.
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24 stories-
IVC to Aorta Ratio Tracks Fluid Response but Lacks Clinical Correlation
Ultrasound metrics of the inferior vena cava change after fluid boluses in pediatric shock but do not align with heart rate or shock index.
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CDR132L Fails to Improve Ventricular Volume After Myocardial Infarction
A phase 2 trial of the microRNA-132 inhibitor CDR132L showed no significant benefit in structural or functional endpoints at six months.
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Chronic Cocaine Use Linked to Rare Baló-Like Concentric Leukoencephalopathy
Two cases in Italy reveal a specific pattern of inflammatory demyelination that responds to steroids but requires cocaine abstinence.
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CFTR Modulators Reduce 8-Year Mortality Risk by 7.2% in Cystic Fibrosis
A registry-based cohort study of 25,103 individuals shows a 66% reduction in the hazard of death following modulator initiation.
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Digitalis Reduces Worsening Heart Failure Events in Large Meta-Analysis
A study of 9,013 patients shows digitalis glycosides lower the risk of worsening heart failure events without affecting mortality.
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Ruxolitinib Resolves Severe Diarrhea Following BCMA-Targeted CAR T-Cell Therapy
A case series suggests JAK inhibition may mitigate the high mortality associated with immune-mediated enterocolitis in multiple myeloma.
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NXT007 Reaches Nonhemophilic Factor VIII Levels in Severe Hemophilia A
A phase 1/2 trial shows monthly subcutaneous NXT007 achieves factor activity above 40 IU/dL and eliminates bleeds at higher doses.
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Carotid Doppler Parameters Predict Return of Spontaneous Circulation During CPR
Waveform-derived metrics like velocity time integral show high predictive value for resuscitation success in emergency department patients.
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Photon-Counting CT Improves Pulmonary Artery Visibility at Lower Radiation Doses
Ultra-high-resolution imaging increases diagnostic confidence and vascular attenuation compared to standard energy-integrating detectors.
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Propofol Reduces Long-Term Water Contamination Compared to Sevoflurane
A modeling study finds sevoflurane leads to irreversible accumulation of trifluoroacetic acid while propofol residues remain biodegradable.
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Penetrating Brain Injury Mortality Reaches 42% While Prophylaxis Compliance Lags
Despite high mortality, 70% of survivors achieve favorable outcomes, though adherence to antibiotic and seizure protocols remains low.
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Tirofiban Improves 90-Day Outcomes After Inadequate Tenecteplase Response
Adjunctive tirofiban increased the rate of functional independence in patients with non-large vessel stroke who failed to improve.
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SMART Model Matches Radiologists in Differentiating New Lung Malignancies
A CT-based tool using semantic features like emphysema and spiculation helps distinguish second primary lung cancers from metastases.
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SSPOP Gene Mutations Linked to Pediatric Epilepsy and Developmental Delay
Researchers identify pathogenic variants in a presumed pseudogene, expanding the diagnostic landscape for unexplained seizure disorders.
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CT Metrics Predict Benralizumab Response in Severe Asthma
Quantitative imaging of small airway disease and sinus opacification identifies responders more accurately than blood eosinophil counts.
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Automated Software Identifies Hundreds of Patients Lost to Aneurysm Follow-Up
Natural language processing of 7.5 million imaging reports captured 492 new patients and generated 47 surgical repairs.
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Perinatal Cash Transfers Linked to 32% Drop in Infant Maltreatment Reports
A study of Flint's Rx Kids program shows unconditional cash support significantly reduces child protective services investigations.
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Preexisting Mental Disorders Increase Mortality After Spinal Injury
A cohort study finds younger patients with dual diagnoses face a 17-fold higher mortality risk following traumatic spinal injury.
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Emergency Eye Calls Often Mask Acute Stroke and TIA
A Danish cohort study reveals that 7.4% of patients hospitalized for primary ocular complaints were ultimately diagnosed with a stroke.
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Low Cardiac Index During Hypotension Increases Acute Kidney Injury Risk
A study of 1,272 cardiac surgery patients finds that hypotension only correlates with renal injury when cardiac index falls below 2.
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Rapid Inter-Temporal Seizure Spread Linked to Poor Surgical Outcomes
Deep learning analysis of 275 seizures shows that extensive cortical involvement and rapid propagation correlate with surgical failure.
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Platelet Transfusion Linked to Higher Mortality in Sepsis Patients
A retrospective study finds transfusions increase ICU stay and thrombosis risk while failing to raise counts in half of septic patients.
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Psychological Factors Predict High-Impact Chronic Pain in Sickle Cell Disease
A prospective study of 90 patients shows that pain catastrophizing and low self-efficacy correlate with sustained functional impairment.
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C1q-Mediated Synaptic Pruning Drives Postoperative Cognitive Decline in Murine Models
Surgical trauma triggers NF-κB signaling and C1q-dependent microglial phagocytosis of hippocampal synapses, leading to memory impairment.