The Briefing · Psychiatry & Cognitive Neurology
Continuous newsroom coverage of evidence in Psychiatry & Cognitive Neurology — newest first.
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Iron Deficiency Drives Dopaminergic Hypersensitivity in Rodent Restless Legs Model
A study in mice links brain iron deficiency to increased GABA release in the striatal-entopeduncular pathway, mimicking opioid withdrawal.
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Routine ICU Delirium Screening Misses 72% of Cases in Spanish Speakers
Caregiver-administered assessments can recover nearly half of missed delirium diagnoses when patient-provider language barriers exist.
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Coping and Self-Efficacy Mediate Mood Improvements in Brain Tumor Caregivers
A secondary analysis of a randomized trial shows that a telehealth intervention reduces anxiety and depression by targeting specific psychological mec
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MTOR Hyperactivation Suppresses Autophagy and Drives Neuroinflammation in Schizophrenia
Restoring cellular waste clearance via mTOR inhibition reduces pro-inflammatory cytokines and glial activation in schizophrenia models.
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Chronotherapeutic Protocol Advances Circadian Timing and Extends Adolescent Sleep
A two-week intervention using light-modulating glasses and scheduling increased weeknight sleep by 47 minutes in high school students.
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Cajanine Reduces Anxiety and Fear Extinction Deficits in Female Mice
The compound modulates the ERβ/NF-κB pathway to alleviate neuroinflammation and behavioral symptoms in a sex-specific manner.
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Elobixibat Improves Chronic Constipation in Patients With Schizophrenia or Depression
Postmarketing surveillance shows increased defecation frequency and improved stool consistency with no serious adverse drug reactions.
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Neural Rhythms in Language and Default-Mode Networks Predict Reading Recall
Combined EEG and MRI data reveal that specific frequency patterns in brain networks correlate with a patient's ability to remember text.
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High-Intensity tACS Improves Chronic Insomnia by Modulating Brain Networks
A randomized trial shows 15 mA stimulation reduces sleep index scores and reorganizes functional connectivity in hyperarousal circuits.
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Childhood Maltreatment Mediates Neural Influence on Depressive Temperament
Hippocampal and insular activity correlate with depressive traits through the subjective appraisal of early life trauma.
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Autism Shares Genetic Risk Loci With Diabetes and Heart Disease
Large-scale genomic analysis identifies 100 shared loci linking autism spectrum disorder to metabolic and cardiovascular phenotypes.
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Infrequent Healthcare Contact and Previous Attempts Linked to Intoxication at Suicide
A Finnish registry study of 6,892 deaths identifies clinical profiles and diagnostic factors associated with acute alcohol use.
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Planetary Health Diet Linked to Lower Risk of Stroke and Depression
A UK Biobank study of 69,370 adults finds high adherence to sustainable eating reduces brain disorder risk via slower biological aging.
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Resilience Alters Symptom Networks Linking Bullying to Depression in Adolescents
Network analysis reveals that low resilience strengthens the ties between social exclusion and depressive symptoms like anhedonia.
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Rising Depressive Symptoms Precede Cardiovascular Disease by Over a Decade
A longitudinal analysis of nearly 50,000 adults identifies a sustained increase in depressive symptoms as a long-term prodromal phase of CVD.
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Early DHEA Levels Predict Depression in Adolescent Males but Not Females
A longitudinal study finds that while DHEA at age nine increases risk for males, adrenal hormones do not explain higher female prevalence.
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Home-Based Prefrontal Cortex Stimulation Reduces Subjective Stress Appraisal
A feasibility study of self-administered tDCS shows high adherence and safety, though physiological stress markers remained unchanged.
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Four Months of Fingolimod Does Not Improve Anxiety or Depression in MS
A prospective study of 61 patients with relapsing-remitting MS found no significant changes in mood scores after initiating fingolimod.
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Students With Moderate Distress Show High Rate of Worsening
A 10-month analysis finds this group is a key target for intervention, with problematic internet use predicting negative outcomes.
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Australian Military Abandons Stratified Suicide Risk for Collaborative Safety Planning
A system-wide initiative removed low, medium, and high risk labels, training over 72,000 personnel in member-centered risk formulation.
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Activities Counter Negative Affect in Depressed, Anhedonic Youth
Real-world data show leisure and social company improve mood primarily by decreasing negative affect, not by increasing positive affect.
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Adolescent Nicotine Rewires Brain Circuitry to Boost Opioid Reward in Mice
Early nicotine exposure alters GABA signaling in the ventral tegmental area, amplifying the rewarding effects of morphine in adult mice.
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Menstrual Cycle Phases Alter Brain Reactivity to Drug Cues
Functional MRI reveals that estrogen heightens cue-induced craving in women with substance use disorders, while progesterone blunts it.
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Alexithymia and Poor Coping Link Trauma to Self-Injury in Depressed Youth
An inability to process emotions drives maladaptive coping, forming a chain reaction that connects early trauma to adolescent self-harm.