Stroke Etiology Does Not Alter Bridging Thrombolysis Efficacy
A meta-analysis of six trials finds no interaction between stroke cause and the benefit of thrombolysis before mechanical thrombectomy.
GNAO1-Related Disorders Follow Non-Degenerative Course Despite Progressive Movement Symptoms
A longitudinal study of 66 patients shows cognitive stability while severe cases face functional burden from worsening movement disorders.
Serum Neurofilament Light Chain Identifies Subclinical Axonal Injury in SMA Neonates
Elevated serum neurofilament light chain levels predict two-year motor outcomes and reveal active denervation before clinical symptoms appear.
Plasma p-Tau217 Matches PET for Modeling Alzheimer's Timelines
Plasma p-tau217 accurately estimates the onset of amyloid and tau pathology, offering an accessible alternative to expensive PET scans.
CD4+ T-Cells Infiltrate Hypocretin Region in Narcolepsy Type 1
Postmortem analysis shows an 11-fold increase in CD4+ T-cells specifically within the hypothalamus, supporting an autoimmune etiology.
Algorithm Predicts Parkinsonism Pathology From Clinical Symptoms
A machine learning tool trained on brain bank data uses 23 clinical parameters to accurately predict post-mortem pathology in parkinsonism.