Comorbidity Drives Genetic Overlap Between Anxiety and Major Depression
Excluding comorbid cases reveals that isolated anxiety and depression are more genetically distinct than previously recognized.
Advanced Paternal Age Increases Autism Risk in Grandchildren via Female Lineage
A registry study of 12.6 million people shows that a grandfather's age at his daughter's birth influences his grandchildren's autism risk.
Bipolar Disorder Linked to Widespread White Matter Network Disruption
Large-scale analysis identifies connectivity deficits in reward circuits associated with illness duration and psychotropic medication use.
Adolescent Depression Linked to Declining Amygdala-Prefrontal Connectivity
Longitudinal imaging shows that escalating depressive symptoms correlate with weakening frontolimbic links during emotion regulation.
Childhood Trauma Linked to Altered Mitochondrial Bioenergetics in Adults
Adults with early life adversity show increased mitochondrial respiratory capacity and reduced glycolytic ATP production in immune cells.
Pyramidal Cell Hypofunction Predicts Psychosis Conversion in High Risk Patients
Biophysical modeling of auditory biomarkers suggests that excitatory deficits, not interneuron dysfunction, drive the transition to psychosis.
Adolescent Nicotine Rewires Brain Circuitry to Boost Opioid Reward in Mice
Early nicotine exposure alters GABA signaling in the ventral tegmental area, amplifying the rewarding effects of morphine in adult mice.
Menstrual Cycle Phases Alter Brain Reactivity to Drug Cues
Functional MRI reveals that estrogen heightens cue-induced craving in women with substance use disorders, while progesterone blunts it.
Nicotine Rewires Habenular Circuits in Mice, Altering Food Motivation
Chronic nicotine exposure in mice disrupts top-down control of the LDT-VTA cholinergic axis, driving exaggerated food-seeking behavior.
Epigenetic Target HDAC5 Reduces Environment-Triggered Cocaine Seeking in Rats
In a rat model, overexpressing the enzyme HDAC5 in the prelimbic cortex shifted synaptic balance to suppress context-driven cocaine seeking.