Brain
Animal Study
GABAA Gain-of-Function Mutation Triggers Seizures via Interneuron Network Collapse in Mice
A study of the GABRB3 p.(Glu77Lys) variant reveals how enhanced inhibitory signaling paradoxically drives cortical hyperexcitability.
Brain
Diagnostic Accuracy Study
Eleven-Protein Plasma Panel Identifies Parkinson’s Disease Across Four Cohorts
A machine learning model using 11 plasma proteins differentiated Parkinson’s from other neurological conditions with high accuracy.
Brain
Cohort Study
Lower Tau PET Sensitivity in Older Men Reflects Reduced Tangle Density
Flortaucipir PET sensitivity for advanced Alzheimer pathology drops to 42% in patients over 83, mirroring lower biological tangle burdens.
Brain
Cohort Study
Glial GLRX3 Enzyme Drives Chronic Oxaliplatin-Induced Pain in Aged Models
A redox circuit in the dorsal root ganglion identifies potential biomarkers and therapeutic targets for age-related chemotherapy toxicity.