Astrocytic Enzyme Regulates Vascular Stability in Alzheimer's Disease Model
Targeting soluble epoxide hydrolase in astrocytes reduced vascular amyloid burden and preserved vasomotion in amyloidosis mice.
Brain Networks Modulate Parkinson's Tremor Amplitude
A large-scale fMRI study identifies distinct brain networks that either produce or actively suppress Parkinson's disease tremor.
Red Blood Cells Contribute Alpha-Synuclein to Parkinson's Brain Pathology
A new study in human tissues and mouse models identifies erythrocytes as a peripheral source of alpha-synuclein, influencing central nervous system.
MIF Modulates Astrocyte Distribution in Schizophrenia Cortical Spheroids
A new study using patient-derived brain models identifies macrophage migration inhibitory factor (MIF) as a key regulator of astrocyte function.
Periventricular Lesions Drive Cognitive Decline by Disrupting Cholinergic Pathways in Parkinson's
White matter injury triggers cortical terminal loss and retrograde atrophy, identifying a structural biomarker for cognitive risk.
PET Imaging Tracks Metabolic Decline Across ALS Clinical Stages
A large cohort study links King's staging to progressive loss of brain connectivity and transient cerebellar recruitment in ALS.
4-Hydroxybenzoic Acid Restores Endogenous Coenzyme Q10 in COQ2-Deficient Patient
A first-in-human trial shows 4-HBA bypasses biosynthetic blocks to improve neurological and renal outcomes in primary CoQ10 deficiency.
Anterior Temporal Atrophy Precedes Semantic Dementia Symptoms by Five Years
Large-scale MRI analysis identifies a prolonged prodromal phase and quantifies the prevalence of incidental anterior temporal lobe loss.
Adenoviral Protein Reactivity Linked to Guillain-Barré Syndrome After COVID-19
Patients with post-infection or post-vaccination GBS show heightened antibody responses to adenoviruses, suggesting a shared trigger.
Biallelic EIPR1 Variants Cause Neurodevelopmental Syndrome and Neutropenia
Defects in endosomal recycling and dense core vesicle biogenesis drive a spectrum of microcephaly, ataxia, and spasticity.
African Ancestry Parkinson’s Disease Linked to Distinct GBA1 and LRRK2 Variants
Genetic screening of 710 African ancestry cases reveals that common European risk variants are absent, replaced by population-specific mutations.
Selective HDAC6 Inhibition Improves Motor Function in Preclinical ALS Models
A CNS-penetrant small molecule restores protein clearance and axonal transport, reducing neurofilament levels and TDP-43 pathology.