Swedish Registry Data Reveal 6-Factor Genetic Structure for Psychiatric Disorders
A large cohort study identifies shared genetic vulnerabilities across 18 psychiatric and substance use disorders, refining diagnostic understanding.
IL-6 Inhibition Shows Clinical Signals in Refractory Depression
A small trial of tocilizumab for difficult-to-treat depression suggests potential for symptom improvement and identifies patient selection markers.
Digital Interventions Improve Eating Disorder Symptoms and Comorbid Mental Health
A meta-analysis of 36 trials shows digital tools offer consistent, durable benefits for core eating disorder symptoms and associated mental health con
Age, Sex, and Initial Diagnosis Shape Mental Disorder Trajectories
A large Danish cohort study details how initial diagnosis, age, and sex influence diagnostic shifts and healthcare utilization.
Lumateperone Leads Efficacy While Aripiprazole Shows Best Acceptability in Depression
A meta-analysis of 10,962 patients quantifies the trade-offs between symptom reduction and treatment adherence for adjunctive antipsychotics.
Intravenous Ketamine Reduces Suicidal Ideation and Depression for One Month
A meta-analysis of 26 trials shows rapid symptom relief within four hours and sustained antisuicidal effects following intravenous infusion.
Prefrontal Stimulation Amplifies Placebo Mood Response in Depression
Intermittent theta burst stimulation of the dorsomedial prefrontal cortex modulates the default mode network to enhance expectancy effects.
Digital and Primary Care Intervention Reduces Adolescent Depressive Symptoms in Slums
A randomized trial in India shows a multimedia campaign and digital tools improve mental health literacy and lower PHQ-9 scores.
Semaglutide Improves Reward-Based Motivation in Patients With Major Depressive Disorder
A randomized trial shows oral semaglutide reduces the perceived cost of physical effort in patients with depression and elevated BMI.
LB-102 Reduces Acute Schizophrenia Symptoms in Phase 2 Trial
A randomized trial of the benzamide derivative LB-102 demonstrated significant PANSS score improvements across three daily dose levels.
Dialectical Behavior Therapy and Schema Therapy Show Similar Efficacy for BPD
A 3-year randomized trial found no significant difference in symptom reduction or dropout between these two intensive psychotherapies.
Clozapine Increases Response After One Failed Antipsychotic in Early Psychosis
A sequential trial reveals that switching to clozapine after a single failed antipsychotic yields a 62.5% response rate in early psychosis.