JAMA psychiatry
Randomized Controlled Trial
Semaglutide Improves Reward-Based Motivation in Patients With Major Depressive Disorder
A randomized trial shows oral semaglutide reduces the perceived cost of physical effort in patients with depression and elevated BMI.
JAMA Psychiatry
Randomized Controlled Trial
LB-102 Reduces Acute Schizophrenia Symptoms in Phase 2 Trial
A randomized trial of the benzamide derivative LB-102 demonstrated significant PANSS score improvements across three daily dose levels.
JAMA Psychiatry
Randomized Controlled Trial
Dialectical Behavior Therapy and Schema Therapy Show Similar Efficacy for BPD
A 3-year randomized trial found no significant difference in symptom reduction or dropout between these two intensive psychotherapies.
JAMA Psychiatry
Randomized Controlled Trial
Clozapine Increases Response After One Failed Antipsychotic in Early Psychosis
A sequential trial reveals that switching to clozapine after a single failed antipsychotic yields a 62.5% response rate in early psychosis.