Algorithm Predicts Mortality in Carbapenem-Resistant ICU Infections
A LightGBM model using routine clinical data accurately predicted 15-day mortality, highlighting coagulopathy and time to antibiotics.
Opioid Medications Halve Mortality but Reach Only a Quarter of Patients
A clinical review details how optimizing methadone, buprenorphine, and naloxone can close the treatment gap and reduce all-cause mortality.
Structured Exercise Improves Sleep and Executive Function in Preteens With Autism
A 10-to-12-week physical activity program objectively reduced sleep fragmentation and improved problem-solving in children with autism.
Continuous Rocuronium Yields Modest Intracranial Pressure Reductions
A retrospective analysis reveals that continuous neuromuscular blockade lowers intracranial pressure by only 1 to 2 mm Hg in severe cases.
Tumor Debulking Adds Toxicity Without Survival Benefit in Metastatic Colorectal Cancer
Adding tumor debulking to chemotherapy fails to extend survival and increases severe adverse events in metastatic colorectal cancer.
White Matter Damage Drives Cognitive Decline via Two Distinct Pathways
In amyloid-negative patients, periventricular lesions directly impair memory but indirectly drive executive dysfunction via hypometabolism.
Schizophrenia Patients Lack Neural Mismatch Response to Unmasked Faces
Patients with schizophrenia fail to generate a normal brain response when internal predictions of a face conflict with new visual input.
Limiting ICU Wrist Restraints Fails to Increase Delirium-Free Days
A restrictive wrist-strap protocol in mechanically ventilated adults did not improve delirium-free days or increase self-extubation risk.
12-Week Diet and Exercise Program Improves Post-ICU Physical Function
A 12-week regimen of exercise and protein supplementation significantly improves physical functioning in long-stay ICU survivors.
Plasma p-Tau217 Matches PET for Modeling Alzheimer's Timelines
Plasma p-tau217 accurately estimates the onset of amyloid and tau pathology, offering an accessible alternative to expensive PET scans.
TBI and Depression Nearly Triple 10-Year Dementia Risk in Veterans
A cohort study of 245,949 veterans shows TBI, depression, and military exposures like Agent Orange significantly increase Alzheimer's risk.
High-Flow Oxygen Lowers Intubation but Does Not Improve Survival
High-flow nasal cannula therapy reduces intubation rates in acute hypoxemic respiratory failure without altering 28-day mortality.