[89Zr]girentuximab PET Identifies Any Renal Malignancy with 98% Positive Predictive Value
A secondary analysis of the ZIRCON trial indicates the CAIX-targeted tracer detects non-clear cell subtypes with high clinical accuracy.
Remote Ischaemic Preconditioning Fails to Prevent Postoperative Myocardial Injury
A randomized trial of two-session preconditioning in abdominal surgery shows no reduction in injury and a paradoxical troponin increase.
Oncology Providers Prioritize Social Support and Symptom Control at End-of-Life
A qualitative study of 49 clinicians reveals how personal values differ by career stage and may influence patient-centered care.
One in Three ICH Patients on Antithrombotics Lack Clinical Indication
A retrospective study finds 30.4% of patients with intracranial hemorrhage were taking unindicated anticoagulants or antiplatelets.
African Populations Underrepresented in High-Impact Clinical Trials
A systematic review of 2,472 trials shows that only 0.6% of cardiovascular studies were conducted exclusively in Africa.
Metacognitive Beliefs Condition the Link Between Somatic Symptoms and Health Anxiety
A survey of 564 adults shows anxiety sensitivity only amplifies health anxiety when patients hold high beliefs about their biased thinking.
Emotional Trauma Drives Adolescent Alexithymia Through Gender-Specific Pathways
Network analysis of 2,447 adolescents identifies emotional abuse and neglect as primary drivers of specific emotional processing deficits.
Injectable Antipsychotics Reduce Hospitalization and Relapse in Bipolar Disorder
A mirror-image study shows paliperidone and aripiprazole long-acting formulations significantly lower psychiatric service use and relapse.
Daily Resistance Training and Verticalization Safe During ECMO Support
A pilot study shows that structured mobility and resistance exercises correlate with improved functional performance in critically ill adults.
Stroke Etiology Does Not Alter Bridging Thrombolysis Efficacy
A meta-analysis of six trials finds no interaction between stroke cause and the benefit of thrombolysis before mechanical thrombectomy.
Specific Combination Therapies Reduce Hospitalization Risk After Lithium Failure
A large cohort study identifies clozapine and long-acting injectable combinations as effective alternatives for maintenance treatment.
Plasma Heme Assay Predicts Mortality Risk in Sickle Cell Disease
Direct quantification of heme species identifies patients with severe hemolysis and exhausted scavenging capacity better than indirect markers.