Ketamine Does Not Reduce 28-Day Mortality Compared With Etomidate
A randomized trial of 2,365 critically ill adults found no survival benefit for ketamine, despite a higher rate of cardiovascular collapse.
Sleep Apnea Prevalence Reaches 69% in Former Professional Football Players
Undiagnosed and untreated sleep apnea significantly correlate with increased pain, anxiety, and cognitive impairment in former athletes.
High Exposure Frequency and Male Gender Predict Problematic Pornography Use
Adults who began viewing pornography as minors show higher risk of problematic use linked to exposure frequency rather than sexual attitudes.
Transcranial Magnetic Stimulation Reduces PTSD Symptoms in Clinical Cohort
A retrospective study of 127 patients found that 65.4% achieved a clinically meaningful reduction in PCL-5 scores following rTMS treatment.
Adolescents at Risk for Bipolar Disorder Show High Self-Harm and Comorbidity Rates
A 12-month study of UK youth finds that those screening positive for bipolar risk receive alternative diagnoses and intensive services.
Alzheimer's and Late-Life Depression Show Divergent Molecular Signatures
Structural MRI and cross-modal mapping reveal distinct neurotransmitter and cellular patterns despite overlapping clinical symptoms.
Early Plasma Reduces Mortality in Traumatic Intracranial Hemorrhage
A retrospective study of 6,183 patients shows a 5% absolute survival drop for every 10-minute delay in plasma during the first half hour.
Social Stress Drives Sex-Specific Molecular Changes in Female Reward Circuitry
Mouse models and human data reveal that social withdrawal in females involves distinct gene expression patterns in the nucleus accumbens.
LB-102 Reduces Acute Schizophrenia Symptoms in Phase 2 Trial
A randomized trial of the benzamide derivative LB-102 demonstrated significant PANSS score improvements across three daily dose levels.
Focal Coronary Disease Predicts Greater Angina Relief After Stenting
New ORBITA-2 data show focal lesions derive significantly more placebo-controlled benefit from PCI than diffuse disease patterns.
Guillain-Barré Syndrome Presents as Catatonic Stupor in Schizophrenia Case
Diminished tendon reflexes and albuminocytologic dissociation distinguish neurologic paralysis from psychiatric immobility.
Gamma Knife Controls Craniopharyngioma but Symptom-Driven Interventions Remain Common
A 108-month study shows 89% 10-year survival, though 28% of patients require further intervention despite radiographic stability.